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    Slc38a10 solute carrier family 38, member 10 [ Mus musculus (house mouse) ]

    Gene ID: 72055, updated on 12-May-2024

    Summary

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    Official Symbol
    Slc38a10provided by MGI
    Official Full Name
    solute carrier family 38, member 10provided by MGI
    Primary source
    MGI:MGI:1919305
    See related
    Ensembl:ENSMUSG00000061306 AllianceGenome:MGI:1919305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810073N04Rik
    Summary
    Predicted to enable amino acid transmembrane transporter activity. Acts upstream of or within bone development. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SLC38A10 (solute carrier family 38 member 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 28.3), subcutaneous fat pad adult (RPKM 28.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E2; 11 83.96 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119994777..120042177, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120103951..120151351, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E206 Neighboring gene TEPSIN, adaptor related protein complex 4 accessory protein Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120011125-120011308 Neighboring gene STARR-positive B cell enhancer ABC_E382 Neighboring gene predicted gene 11769 Neighboring gene predicted gene, 39486 Neighboring gene STARR-seq mESC enhancer starr_31342 Neighboring gene predicted gene 9734 Neighboring gene regulator of early neurogenesis 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and Histidine in Males but Not in Females: A Preliminary Characterization Study of SLC38A10(-/-) Mice. Lindberg FA, et al. Genes (Basel), 2023 Mar 30. PMID 37107593, Free PMC Article
    2. Behavioral profiling of SLC38A10 knockout mice using the multivariate concentric square field(TM) test. Lindberg FA, et al. Front Behav Neurosci, 2022. PMID 36620864, Free PMC Article
    3. SLC38A10 Knockout Mice Display a Decreased Body Weight and an Increased Risk-Taking Behavior in the Open Field Test. Lindberg FA, et al. Front Behav Neurosci, 2022. PMID 35677577, Free PMC Article
    4. SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells. Tripathi R, et al. Front Cell Dev Biol, 2022. PMID 35450293, Free PMC Article
    5. SLC38A10 Transporter Plays a Role in Cell Survival Under Oxidative Stress and Glutamate Toxicity. Tripathi R, et al. Front Mol Biosci, 2021. PMID 34026845, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and Histidine in Males but Not in Females: A Preliminary Characterization Study of SLC38A10[-/-] Mice.
      Title: SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and Histidine in Males but Not in Females: A Preliminary Characterization Study of SLC38A10(-/-) Mice.
    2. we have shown that SNAT10 expression is found in most neurons of the mouse brain. It has a unique intracellular localization in several cell lines, strongly suggesting expression in the Golgi. Silencing the expression of SNAT10 in PC12 cells resulted in the reduction of nascent protein synthesis, suggesting that SNAT10 might function as a transceptor.
      Title: SLC38A10 (SNAT10) is Located in ER and Golgi Compartments and Has a Role in Regulating Nascent Protein Synthesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 38 member 10
    Names
    amino acid transporter SLC38A10
    novel amino acid transporter protein
    putative sodium-coupled neutral amino acid transporter 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164798.1 → NP_001158270.1  solute carrier family 38 member 10 isoform 2

      See identical proteins and their annotated locations for NP_001158270.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK032245, BC088811, BY308707, BY630861
      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (2) summary
      COG0814
      Location:3 → 397
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001164799.1 → NP_001158271.1  solute carrier family 38 member 10 isoform 3

      See identical proteins and their annotated locations for NP_001158271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK032245, AK159948, BY308707, BY630861
      Consensus CDS
      CCDS49000.1
      UniProtKB/TrEMBL
      J3QNE8
      Related
      ENSMUSP00000048675.8, ENSMUST00000045402.14
      Conserved Domains (2) summary
      COG0814
      Location:3 → 397
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_001164800.1 → NP_001158272.1  solute carrier family 38 member 10 isoform 4

      See identical proteins and their annotated locations for NP_001158272.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AK032245, BC082300, BY308707, BY630861
      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (2) summary
      COG0814
      Location:3 → 397
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_001164801.1 → NP_001158273.1  solute carrier family 38 member 10 isoform 5

      See identical proteins and their annotated locations for NP_001158273.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL807824, BC082300, BY308707
      Consensus CDS
      CCDS49002.1
      UniProtKB/Swiss-Prot
      Q5I012
      Related
      ENSMUSP00000057615.9, ENSMUST00000053692.9
      Conserved Domains (1) summary
      cl00456
      Location:6 → 372
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. NM_001164802.1 → NP_001158274.1  solute carrier family 38 member 10 isoform 6

      See identical proteins and their annotated locations for NP_001158274.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 6) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK007977, BY308707
      Consensus CDS
      CCDS49001.1
      UniProtKB/Swiss-Prot
      Q5I012
      Related
      ENSMUSP00000075989.7, ENSMUST00000076697.13
      Conserved Domains (1) summary
      cl00456
      Location:6 → 378
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    6. NM_001361696.1 → NP_001348625.1  solute carrier family 38 member 10 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL807824
      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      pfam03157
      Location:527 → 1010
      Glutenin_hmw; High molecular weight glutenin subunit
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
      cl26511
      Location:407 → 766
      Neuromodulin_N; Gap junction protein N-terminal region

    7. NM_001361697.1 → NP_001348626.1  solute carrier family 38 member 10 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL807824
      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      cl00456
      Location:2 → 299
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
      cl25751
      Location:628 → 887
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:325 → 685
      Neuromodulin_N; Gap junction protein N-terminal region

    8. NM_001361698.1 → NP_001348627.1  solute carrier family 38 member 10 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL807824
      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      cl00456
      Location:6 → 293
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
      cl25751
      Location:622 → 882
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:319 → 682
      Neuromodulin_N; Gap junction protein N-terminal region

    9. NM_001361699.1 → NP_001348628.1  solute carrier family 38 member 10 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL807824
      Conserved Domains (3) summary
      PTZ00121
      Location:182 → 545
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:485 → 745
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:8 → 156
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    10. NM_024249.5 → NP_077211.4  solute carrier family 38 member 10 isoform 1

      See identical proteins and their annotated locations for NP_077211.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK032245, BC088811, BY308707, BY630861
      Consensus CDS
      CCDS25728.1
      UniProtKB/Swiss-Prot
      A2AMZ5, Q3TVW4, Q5I012, Q641M1, Q80ZZ4, Q8C1Y0, Q8CCR5, Q9D8J3
      UniProtKB/TrEMBL
      J3QNE8
      Related
      ENSMUSP00000099307.5, ENSMUST00000103018.11
      Conserved Domains (2) summary
      COG0814
      Location:3 → 397
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      119994777..120042177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246350.1 → XP_030102210.1  solute carrier family 38 member 10 isoform X8

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:407 → 724
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:667 → 926
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_017314782.1 → XP_017170271.1  solute carrier family 38 member 10 isoform X7

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (2) summary
      PTZ00121
      Location:407 → 954
      PTZ00121; MAEBL; Provisional
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_030246349.1 → XP_030102209.1  solute carrier family 38 member 10 isoform X6

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:407 → 758
      PTZ00121; MAEBL; Provisional
      pfam03157
      Location:552 → 997
      Glutenin_hmw; High molecular weight glutenin subunit
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_006534288.3 → XP_006534351.1  solute carrier family 38 member 10 isoform X5

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:407 → 759
      PTZ00121; MAEBL; Provisional
      pfam03157
      Location:552 → 998
      Glutenin_hmw; High molecular weight glutenin subunit
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. XM_006534287.3 → XP_006534350.1  solute carrier family 38 member 10 isoform X4

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:407 → 767
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:709 → 969
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    6. XM_006534285.3 → XP_006534348.1  solute carrier family 38 member 10 isoform X2

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:407 → 788
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:730 → 990
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    7. XM_006534286.3 → XP_006534349.1  solute carrier family 38 member 10 isoform X3

      See identical proteins and their annotated locations for XP_006534349.1

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:407 → 788
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:731 → 990
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    8. XM_030246352.2 → XP_030102212.1  solute carrier family 38 member 10 isoform X11

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:325 → 688
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:628 → 888
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:2 → 299
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    9. XM_006534284.3 → XP_006534347.1  solute carrier family 38 member 10 isoform X1

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:407 → 789
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:731 → 991
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    10. XM_036157009.1 → XP_036012902.1  solute carrier family 38 member 10 isoform X15

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:319 → 674
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:614 → 874
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:6 → 293
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    11. XM_006534291.3 → XP_006534354.1  solute carrier family 38 member 10 isoform X10

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:319 → 701
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:643 → 903
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:6 → 293
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    12. XM_030246351.1 → XP_030102211.1  solute carrier family 38 member 10 isoform X9

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:325 → 707
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:649 → 909
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:2 → 299
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    13. XM_036157008.1 → XP_036012901.1  solute carrier family 38 member 10 isoform X14

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:325 → 680
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:620 → 880
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:2 → 299
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    14. XM_030246354.1 → XP_030102214.1  solute carrier family 38 member 10 isoform X13

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:325 → 684
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:627 → 886
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:2 → 299
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    15. XM_030246353.1 → XP_030102213.1  solute carrier family 38 member 10 isoform X12

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:325 → 685
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:627 → 887
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:2 → 299
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    16. XM_006534290.3 → XP_006534353.1  solute carrier family 38 member 10 isoform X9

      UniProtKB/TrEMBL
      J3QNE8
      Conserved Domains (3) summary
      PTZ00121
      Location:325 → 707
      PTZ00121; MAEBL; Provisional
      PTZ00449
      Location:649 → 909
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl00456
      Location:2 → 299
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I012.2 GenPept UniProtKB/Swiss-Prot:Q5I012

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