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    ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [ Varanus komodoensis (Komodo dragon) ]

    Gene ID: 123017286, updated on 22-Mar-2024

    Summary

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    Gene symbol
    ARAP1
    Gene description
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
    See related
    Ensembl:ENSVKKG00000015801
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Varanus komodoensis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus
    Orthologs
    human mouse all
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    Genomic context

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    See ARAP1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    100 current ASM479886v1 (GCF_004798865.1) Unplaced Scaffold NW_025336610.1 (931825..1017895)

    NW_025336610.1Genomic Context describing neighboring genes Neighboring gene ClpB family mitochondrial disaggregase Neighboring gene StAR related lipid transfer domain containing 10 Neighboring gene phosphodiesterase 2A Neighboring gene disintegrin and metalloproteinase domain-containing protein 21-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_025336610 Unplaced Scaffold Reference ASM479886v1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Varanus komodoensis Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM479886v1

    Genomic

    1. NW_025336610.1 Reference ASM479886v1

      Range
      931825..1017895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_044418543.1 → XP_044274478.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8D2LKP8
      Related
      ENSVKKP00000023970.1, ENSVKKT00000024556.1
      Conserved Domains (9) summary
      cd04385
      Location:1009 → 1187
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:382 → 474
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:495 → 579
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:797 → 902
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13259
      Location:1315 → 1442
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17226
      Location:1223 → 1315
      RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
      cl28907
      Location:590 → 704
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      cl15755
      Location:4 → 66
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:916 → 1004
      PH-like; Pleckstrin homology-like domain

    2. XM_044418542.1 → XP_044274477.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8D2LKP8
      Conserved Domains (9) summary
      cd04385
      Location:1009 → 1187
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:382 → 474
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:495 → 579
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:797 → 902
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13259
      Location:1315 → 1442
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17226
      Location:1223 → 1315
      RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
      cl28907
      Location:590 → 704
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      cl15755
      Location:4 → 66
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:916 → 1004
      PH-like; Pleckstrin homology-like domain

    3. XM_044418544.1 → XP_044274479.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8D2LKP8
      Conserved Domains (9) summary
      cd04385
      Location:1008 → 1186
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:381 → 473
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:494 → 578
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:796 → 901
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13259
      Location:1314 → 1441
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17226
      Location:1222 → 1314
      RA_ARAP1; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1)
      cl28907
      Location:589 → 703
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      cl15755
      Location:4 → 66
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:915 → 1003
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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