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    PVALB parvalbumin [ Canis lupus familiaris (dog) ]

    Gene ID: 481278, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PVALBprovided by VGNC
    Official Full Name
    parvalbuminprovided by VGNC
    Primary source
    VGNC:VGNC:45214
    See related
    Ensembl:ENSCAFG00845008220
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PVALB in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (28447846..28466434)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (27610209..27628586)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (28656677..28675084)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (28169344..28187929)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (28477867..28496446)

    Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 4 Neighboring gene colony stimulating factor 2 receptor subunit beta Neighboring gene neutrophil cytosolic factor 4 Neighboring gene intraflagellar transport 27 Neighboring gene uncharacterized LOC111097658

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parvalbumin alters mitochondrial dynamics and affects cell morphology. Lichvarova L, et al. Cell Mol Life Sci, 2018 Dec. PMID 30255402, Free PMC Article
    2. Parvalbumin expression in the claustrum of the adult dog. An immunohistochemical and topographical study with comparative notes on the structure of the nucleus. Pirone A, et al. J Chem Neuroanat, 2015 Mar-Apr. PMID 25724540
    3. Sustained expression of parvalbumin immunoreactivity in the hippocampal CA1 region and dentate gyrus during aging in dogs. Hwang IK, et al. Neurosci Lett, 2008 Mar 21. PMID 18280652
    4. Immunocytochemical localization of calcium-binding proteins, calbindin D28K-, calretinin-, and parvalbumin-containing neurons in the dog visual cortex. Yu SH, et al. Zoolog Sci, 2011 Sep. PMID 21882959
    5. Age-related changes in calbindin-D28k, parvalbumin, and calretinin immunoreactivity in the dog main olfactory bulb. Choi JH, et al. Cell Mol Neurobiol, 2010 Jan. PMID 19533334

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Constitutive parvalbumin down-regulation in parvalbumin-overexpressing cells reverted mitochondrial morphology and fractional volume to the state present in control MDCK cells, resulting from increased mitochondrial movement and augmented fusion rates.
      Title: Parvalbumin alters mitochondrial dynamics and affects cell morphology.
    2. The topographical distribution of parvalbumin immunoreactivity suggests that the dog dorsal claustrum might be functionally related to the processing of visual inputs
      Title: Parvalbumin expression in the claustrum of the adult dog. An immunohistochemical and topographical study with comparative notes on the structure of the nucleus.
    3. This study elucidates the neurochemical structure of calcium-binding proteins which will be informative for the functional significance of different laminar distributions of calcium-binding proteins between species.
      Title: Immunocytochemical localization of calcium-binding proteins, calbindin D28K-, calretinin-, and parvalbumin-containing neurons in the dog visual cortex.
    4. Expression and age-related changes of calbindin-D28k (CB), parvalbumin (PV), and calretinin (CR) in the main olfactory bulb of the dog were investigated by immunohistochemistry and western blot analysis.
      Title: Age-related changes in calbindin-D28k, parvalbumin, and calretinin immunoreactivity in the dog main olfactory bulb.
    5. In 3-year-old dogs, PV immunoreactivity was higher in the CA1 region and dentate gyrus, and this was maintained in 10-year-old dogs. PV immunoreactive interneurons show resistance to age-dependent neurodegenerative processes.
      Title: Sustained expression of parvalbumin immunoreactivity in the hippocampal CA1 region and dentate gyrus during aging in dogs.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    parvalbumin alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051814.1 Reference ROS_Cfam_1.0

      Range
      28447846..28466434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038679967.1 → XP_038535895.1  parvalbumin alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0JV05
      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    2. XM_038679970.1 → XP_038535898.1  parvalbumin alpha isoform X2

      UniProtKB/TrEMBL
      A0A8C0JV05, A0A8C0SA21, A0A8I3N7Z7
      Related
      ENSCAFP00845011208.1, ENSCAFT00845014467.1
      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    3. XM_038679968.1 → XP_038535896.1  parvalbumin alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0JV05
      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    4. XM_038679966.1 → XP_038535894.1  parvalbumin alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0JV05
      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    5. XM_038679969.1 → XP_038535897.1  parvalbumin alpha isoform X2

      UniProtKB/TrEMBL
      A0A8C0JV05, A0A8C0SA21, A0A8I3N7Z7
      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049270.1 Alternate UMICH_Zoey_3.1

      Range
      28169344..28187929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038488713.1 → XP_038344641.1  parvalbumin alpha isoform X1

      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    2. XM_038488716.1 → XP_038344644.1  parvalbumin alpha isoform X2

      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    3. XM_038488714.1 → XP_038344642.1  parvalbumin alpha isoform X1

      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    4. XM_038488712.1 → XP_038344640.1  parvalbumin alpha isoform X1

      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    5. XM_038488715.1 → XP_038344643.1  parvalbumin alpha isoform X2

      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

      Range
      28477867..28496446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038614607.1 → XP_038470535.1  parvalbumin alpha isoform X1

      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    2. XM_038614610.1 → XP_038470538.1  parvalbumin alpha isoform X2

      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    3. XM_038614608.1 → XP_038470536.1  parvalbumin alpha isoform X1

      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    4. XM_038614606.1 → XP_038470534.1  parvalbumin alpha isoform X1

      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    5. XM_038614609.1 → XP_038470537.1  parvalbumin alpha isoform X2

      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

      Range
      28656677..28675084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038550676.1 → XP_038406604.1  parvalbumin alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0JV05
      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    2. XM_038550680.1 → XP_038406608.1  parvalbumin alpha isoform X2

      UniProtKB/TrEMBL
      A0A8C0JV05, A0A8C0SA21, A0A8I3N7Z7
      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    3. XM_038550678.1 → XP_038406606.1  parvalbumin alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0JV05
      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    4. XM_038550675.1 → XP_038406603.1  parvalbumin alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0JV05
      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    5. XM_038550679.1 → XP_038406607.1  parvalbumin alpha isoform X2

      UniProtKB/TrEMBL
      A0A8C0JV05, A0A8C0SA21, A0A8I3N7Z7
      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      27610209..27628586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022424478.2 → XP_022280186.1  parvalbumin alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0JV05
      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    2. XM_003431505.4 → XP_003431553.1  parvalbumin alpha isoform X2

      See identical proteins and their annotated locations for XP_003431553.1

      UniProtKB/TrEMBL
      A0A8C0JV05, A0A8C0SA21, A0A8I3N7Z7
      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    3. XM_022424477.2 → XP_022280185.1  parvalbumin alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0JV05
      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    4. XM_022424476.2 → XP_022280184.1  parvalbumin alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0JV05
      Conserved Domains (1) summary
      cd16254
      Location:9 → 105
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

    5. XM_538399.7 → XP_538399.2  parvalbumin alpha isoform X2

      See identical proteins and their annotated locations for XP_538399.2

      UniProtKB/TrEMBL
      A0A8C0JV05, A0A8C0SA21, A0A8I3N7Z7
      Conserved Domains (1) summary
      cd16254
      Location:9 → 109
      EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin
    Nucleotide Protein
    Heading Accession and Version

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