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    apc2 adenomatosis polyposis coli 2 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100487473, updated on 25-Apr-2024

    Summary

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    Official Symbol
    apc2provided by Xenbase
    Official Full Name
    adenomatosis polyposis coli 2provided by Xenbase
    Primary source
    Xenbase:XB-GENE-995291
    See related
    Ensembl:ENSXETG00000039922
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    apcl
    Orthologs
    human mouse all
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    Genomic context

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    See apc2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (99434034..99457617, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (80476571..80500138, complement)

    Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 6 Neighboring gene chromosome 1 C19orf25 homolog Neighboring gene gap junction beta-1 protein-like Neighboring gene ribosomal protein S15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenomatous polyposis coli protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      99434034..99457617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012954604.3 → XP_012810058.1  adenomatous polyposis coli protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8J0SAM4
      Conserved Domains (9) summary
      cd00020
      Location:544 → 663
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:1434 → 1458
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:1366 → 1384
      SAMP; SAMP Motif
      pfam05937
      Location:2263 → 2284
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:1869 → 2137
      APC_basic; APC basic domain
      pfam11414
      Location:109 → 183
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:666 → 940
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:14 → 65
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:496 → 529
      ARM; armadillo repeat [structural motif]

    2. XM_002941120.5 → XP_002941166.2  adenomatous polyposis coli protein 2 isoform X1

      See identical proteins and their annotated locations for XP_002941166.2

      UniProtKB/TrEMBL
      A0A6I8RPK8
      Related
      ENSXETP00000084404.1, ENSXETT00000069029.2
      Conserved Domains (12) summary
      smart00185
      Location:603 → 643
      ARM; Armadillo/beta-catenin-like repeats
      TIGR02168
      Location:21 → 435
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00043
      Location:516 → 549
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:650 → 683
      Arm; Armadillo/beta-catenin-like repeat
      pfam05923
      Location:1454 → 1476
      APC_r; APC repeat
      pfam05924
      Location:1384 → 1404
      SAMP; SAMP Motif
      pfam05937
      Location:2283 → 2304
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:1889 → 2157
      APC_basic; APC basic domain
      pfam11414
      Location:130 → 203
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:686 → 960
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:14 → 65
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam18797
      Location:348 → 420
      APC_rep; Adenomatous polyposis coli (APC) repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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