actn1 actinin, alpha 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: actn1provided by ZNC
Official Full Name: actinin, alpha 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-081113-4
See related: Ensembl:ENSDARG00000007219 AllianceGenome:ZFIN:ZDB-GENE-081113-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and muscle cell development. Predicted to be active in several cellular components, including Z disc; actin cytoskeleton; and cell junction. Is expressed in several structures, including head muscle; intestine; nervous system; ovary; and ventral intermandibularis anterior. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 15. Orthologous to human ACTN1 (actinin alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (36321088..36391531, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (36195259..36265698, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle cell development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-actinin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168286.2 → NP_001161758.1 alpha-actinin-1

See identical proteins and their annotated locations for NP_001161758.1

Status: VALIDATED

Source sequence(s)

CA476190, CF995888, CK141214, CR361558

UniProtKB/TrEMBL

B8JHU4, F6NZE7

Related

ENSDARP00000090990.3, ENSDART00000100217.5

Conserved Domains (7) summary

cd00014
Location:155 → 259

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:760 → 827

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:405 → 632

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:42 → 140

CH; Calponin homology (CH) domain

pfam00435
Location:640 → 743

Spectrin; Spectrin repeat

pfam08726
Location:832 → 898

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:762 → 826

EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

36321088..36391531 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009307476.3 → XP_009305751.1 alpha-actinin-1 isoform X3

UniProtKB/TrEMBL

A0A8M3AZC5

Conserved Domains (7) summary

cd00014
Location:155 → 259

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:760 → 822

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:405 → 632

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:42 → 140

CH; Calponin homology (CH) domain

pfam00435
Location:640 → 743

Spectrin; Spectrin repeat

pfam08726
Location:827 → 893

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:762 → 821

EF-hand_7; EF-hand domain pair
XM_009307474.3 → XP_009305749.1 alpha-actinin-1 isoform X1

UniProtKB/TrEMBL

A0A8M3B867

Conserved Domains (7) summary

cd00014
Location:155 → 259

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:760 → 827

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:405 → 632

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:42 → 140

CH; Calponin homology (CH) domain

pfam00435
Location:640 → 743

Spectrin; Spectrin repeat

pfam08726
Location:832 → 898

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:762 → 826

EF-hand_7; EF-hand domain pair
XM_009307475.3 → XP_009305750.1 alpha-actinin-1 isoform X2

UniProtKB/TrEMBL

A0A8M3B5E5

Conserved Domains (7) summary

cd00014
Location:155 → 259

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:760 → 822

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:405 → 632

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:42 → 140

CH; Calponin homology (CH) domain

pfam00435
Location:640 → 743

Spectrin; Spectrin repeat

pfam08726
Location:827 → 893

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:762 → 821

EF-hand_7; EF-hand domain pair
XM_005156996.4 → XP_005157053.1 alpha-actinin-1 isoform X5

UniProtKB/TrEMBL

A0A8M2B3U1

Conserved Domains (7) summary

cd00014
Location:155 → 259

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:760 → 849

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:405 → 632

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:42 → 140

CH; Calponin homology (CH) domain

pfam00435
Location:640 → 743

Spectrin; Spectrin repeat

pfam08726
Location:854 → 920

EFhand_Ca_insen; Ca2+ insensitive EF hand

pfam13499
Location:762 → 848

EF-hand_7; EF-hand domain pair
XM_021480596.1 → XP_021336271.1 alpha-actinin-1 isoform X4

UniProtKB/TrEMBL

A0A8M9QJP5

Conserved Domains (5) summary

COG5069
Location:1 → 54

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:512 → 579

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:157 → 384

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:392 → 495

Spectrin; Spectrin repeat

pfam08726
Location:584 → 650

EFhand_Ca_insen; Ca2+ insensitive EF hand