Rxfp1 relaxin/insulin-like family peptide receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rxfp1provided by MGI
Official Full Name: relaxin/insulin-like family peptide receptor 1provided by MGI
Primary source: MGI:MGI:2682211
See related: Ensembl:ENSMUSG00000034009 AllianceGenome:MGI:2682211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lgr7; Gm1018
Summary: Enables hormone binding activity. Acts upstream of or within several processes, including lung connective tissue development; nipple morphogenesis; and parturition. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain and metanephros. Orthologous to human RXFP1 (relaxin family peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 9.6), cortex adult (RPKM 2.8) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E3; 3 34.94 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (79548910..79645258, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (79641600..79737951, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis.
Title: Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis.
This study demonstrates the involvement of ADAM10 and PI3K/Akt signaling in mediating RLX-induced Notch-1 activation.
Title: Relaxin induces up-regulation of ADAM10 metalloprotease in RXFP1-expressing cells by PI3K/AKT signaling.
No differences were found in RXFP1 expression related to aging.
Title: Differential effects of relaxin deficiency on vascular aging in arteries of male mice.
Colonic tissue expresses RXFP1 in smooth muscle cells of the muscular wall and in neurons of the myenteric plexus.
Title: Relaxin Affects Smooth Muscle Biophysical Properties and Mechanical Activity of the Female Mouse Colon.
relaxin/RXFP1 signaling in smooth muscle cells is important for normal collagen turnover and relaxation of the pubic symphysis during pregnancy
Title: Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice.
Rxfp1, Rxfp2, and Nr3c1 mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5.
Title: Relaxin receptors 1 and 2 and nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) mRNAs are expressed in oral components of developing mice.
maternal exposure to simazine causes disturbed relaxin signaling pathway and testicular dysfunction
Title: Disturbed relaxin signaling pathway and testicular dysfunction in mouse offspring upon maternal exposure to simazine.
H3 relaxin exerts antifibrotic actions via RXFP1 receptor
Title: H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor.
The downregulation of RXFP1 resulted in significant decrease in metastasis rate in PC3 tumors.
Title: Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis.
Rxfp1 acts in an autocrine and/or paracrine fashion upstream of PCDHY in regulating increased canonical Wnt signaling in prostate cancer.
Title: Relaxin drives Wnt signaling through upregulation of PCDHY in prostate cancer.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC343807P1 (e-PCR)
- UniSTS:273191

D3Mit244.2 (e-PCR), detects polymorphism
- UniSTS:129666

B332 (e-PCR)
- UniSTS:129686

D3Mit26.2 (e-PCR), detects polymorphism
- UniSTS:129687

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lung connective tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myofibroblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nipple morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within parturition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: relaxin receptor 1

Names: leucine-rich repeat-containing 7; leucine-rich repeat-containing G-protein coupled receptor 7; relaxin family peptide receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212452.3 → NP_997617.1 relaxin receptor 1 precursor

See identical proteins and their annotated locations for NP_997617.1

Status: VALIDATED

Source sequence(s)

AC122462, AC159281

Consensus CDS

CCDS17420.1

UniProtKB/Swiss-Prot

Q6R6I7, Q80UD3

Related

ENSMUSP00000077611.6, ENSMUST00000078527.13

Conserved Domains (6) summary

cd00112
Location:27 → 62

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:147 → 331

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:110 → 127

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:128 → 151

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:422 → 681

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:151 → 210

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

79548910..79645258 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252661.2 → XP_030108521.1 relaxin receptor 1 isoform X2

Conserved Domains (5) summary

sd00033
Location:2 → 22

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:22 → 81

LRR_8; Leucine rich repeat

cd14964
Location:279 → 303

7tm_GPCRs; TM helix 1 [structural motif]

NF033189
Location:2 → 234

internalin_A; class 1 internalin InlA

cl28897
Location:277 → 563

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006501629.3 → XP_006501692.1 relaxin receptor 1 isoform X1

Conserved Domains (5) summary

cd00112
Location:27 → 62

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

sd00033
Location:128 → 151

LRR_RI; leucine-rich repeat [structural motif]

cd15965
Location:405 → 691

7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors

pfam13855
Location:151 → 210

LRR_8; Leucine rich repeat

NF033189
Location:126 → 334

internalin_A; class 1 internalin InlA
XM_030252662.2 → XP_030108522.1 relaxin receptor 1 isoform X3

Conserved Domains (5) summary

COG4886
Location:9 → 145

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:20 → 43

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:43 → 102

LRR_8; Leucine rich repeat

cd14964
Location:178 → 204

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:177 → 463

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily