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    Rufy2 RUN and FYVE domain-containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 70432, updated on 12-May-2024

    Summary

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    Official Symbol
    Rufy2provided by MGI
    Official Full Name
    RUN and FYVE domain-containing 2provided by MGI
    Primary source
    MGI:MGI:1917682
    See related
    Ensembl:ENSMUSG00000020070 AllianceGenome:MGI:1917682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Denn; LZ-FYVE; ZFYVE13; 2610111M19Rik
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; respiratory system; sensory organ; skeleton; and skin. Orthologous to human RUFY2 (RUN and FYVE domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.0), CNS E14 (RPKM 10.6) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rufy2 in Genome Data Viewer
    Location:
    10 B4; 10 32.51 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62815947..62852988)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62980174..63017209)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62409633-62409742 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene STARR-seq mESC enhancer starr_26916 Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene predicted gene 16143 Neighboring gene phenazine biosynthesis-like protein domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LZ-FYVE: a novel developmental stage-specific leucine zipper, FYVE-finger protein. Dunkelberg JC, et al. DNA Cell Biol, 2001 Jul. PMID 11506704
    2. Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking. Yang J, et al. J Biol Chem, 2002 Aug 16. PMID 11877430
    3. Rufy3, a protein specifically expressed in neurons, interacts with actin-bundling protein Fascin to control the growth of axons. Wei Z, et al. J Neurochem, 2014 Sep. PMID 24720729
    4. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article
    5. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RUN and FYVE domain-containing protein 2
    Names
    leucine zipper FYVE-finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027425.4 → NP_081701.2  RUN and FYVE domain-containing protein 2

      See identical proteins and their annotated locations for NP_081701.2

      Status: VALIDATED

      Source sequence(s)
      AC113107
      Consensus CDS
      CCDS48582.1
      UniProtKB/Swiss-Prot
      Q69ZH1, Q8R4C2
      UniProtKB/TrEMBL
      B2RQ36
      Related
      ENSMUSP00000113429.2, ENSMUST00000119567.8
      Conserved Domains (6) summary
      cd15759
      Location:534 → 604
      FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
      pfam02759
      Location:45 → 168
      RUN; RUN domain
      pfam06156
      Location:223 → 295
      DUF972; Protein of unknown function (DUF972)
      pfam09728
      Location:209 → 535
      Taxilin; Myosin-like coiled-coil protein
      cd16269
      Location:497 → 507
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:326 → 510
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62815947..62852988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514087.3 → XP_006514150.1  RUN and FYVE domain-containing protein 2 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:210 → 535
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd15759
      Location:533 → 603
      FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
      pfam02759
      Location:45 → 166
      RUN; RUN domain

    2. XM_036156001.1 → XP_036011894.1  RUN and FYVE domain-containing protein 2 isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:13 → 266
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl28890
      Location:268 → 338
      FYVE_like_SF; FYVE domain like superfamily

    3. XM_011243562.4 → XP_011241864.1  RUN and FYVE domain-containing protein 2 isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:165 → 520
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd15759
      Location:518 → 588
      FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
      pfam02759
      Location:29 → 150
      RUN; RUN domain

    RNA

    1. XR_004936273.1 RNA Sequence

    2. XR_003948801.2 RNA Sequence

    3. XR_004936275.1 RNA Sequence

    4. XR_004936272.1 RNA Sequence

    5. XR_003948799.2 RNA Sequence

    6. XR_003948800.2 RNA Sequence

    7. XR_003948802.2 RNA Sequence

    8. XR_004936274.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4C2.2 GenPept UniProtKB/Swiss-Prot:Q8R4C2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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