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    SLCO4A1 solute carrier organic anion transporter family member 4A1 [ Homo sapiens (human) ]

    Gene ID: 28231, updated on 3-Apr-2024

    Summary

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    Official Symbol
    SLCO4A1provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 4A1provided by HGNC
    Primary source
    HGNC:HGNC:10953
    See related
    Ensembl:ENSG00000101187 MIM:612436; AllianceGenome:HGNC:10953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POAT; OATP1; OATPE; OATP-E; OATP4A1; OATPRP1; SLC21A12
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in esophagus (RPKM 2.4), endometrium (RPKM 1.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLCO4A1 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62642503..62690740)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64441223..64489475)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61273855..61303645)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61266847-61267348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61267349-61267848 Neighboring gene uncharacterized LOC124904949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61279493-61280066 Neighboring gene SLCO4A1 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18213 Neighboring gene SLCO4A1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61302735-61303693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61314847-61315390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61315391-61315933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61339152-61339665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61339666-61340178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61340388-61340934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61340935-61341479 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61352726-61352918 Neighboring gene neurotensin receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61354746-61355285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61366135-61366980 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:61371112-61372311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61392433-61393212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61400285-61401016 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61407515-61407676 Neighboring gene long intergenic non-protein coding RNA 659

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Abundance of the Organic Anion-transporting Polypeptide OATP4A1 in Early-Stage Colorectal Cancer Patients: Association With Disease Relapse. Buxhofer-Ausch V, et al. Appl Immunohistochem Mol Morphol, 2019 Mar. PMID 29734253
    2. Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer. Ban MJ, et al. J Cancer Res Clin Oncol, 2017 Aug. PMID 28378090
    3. Identification of steroid sulfate transport processes in the human mammary gland. Pizzagalli F, et al. J Clin Endocrinol Metab, 2003 Aug. PMID 12915686
    4. Effect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer. Rawłuszko-Wieczorek AA, et al. Biomed Pharmacother, 2015 Aug. PMID 26349991
    5. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Fujiwara K, et al. Endocrinology, 2001 May. PMID 11316767

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLCO4A1, as a novel prognostic biomarker of non-small cell lung cancer, promotes cell proliferation and migration.
      Title: SLCO4A1, as a novel prognostic biomarker of non‑small cell lung cancer, promotes cell proliferation and migration.
    2. Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy.
      Title: Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy.
    3. Abundance of the Organic Anion-transporting Polypeptide OATP4A1 in Early-Stage Colorectal Cancer Patients: Association With Disease Relapse.
      Title: Abundance of the Organic Anion-transporting Polypeptide OATP4A1 in Early-Stage Colorectal Cancer Patients: Association With Disease Relapse.
    4. SLCO4A1 may be a valuable marker of poor prognostic for colorectal cancer (CRC). Furthermore, SLCO4A1 plays an important role in CRC cell proliferation, migration, invasion, and carcinogenesis
      Title: Solute carrier organic anion transporter family member 4A1 (SLCO4A1) as a prognosis marker of colorectal cancer.
    5. our results revealed altered OATP3A1 and OATP4A1 mRNA levels and novel mechanisms that might be involved in their regulation in colorectal cancer
      Title: Effect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer.
    6. High OATP4A1 expression is associated with small cell lung cancer.
      Title: Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy.
    7. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.
      Title: The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
    9. oligomerization of Oatp1a1 with PDZK1 is critical for its proper subcellular localization and function
      Title: Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLCO4A1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prostaglandin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thyroid hormone transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prostaglandin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thyroid hormone transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 4A1
    Names
    OATP-RP1
    colon organic anion transporter
    organic anion transporter polypeptide-related protein 1
    organic anion transporting polypeptide E
    sodium-independent organic anion transporter E
    solute carrier family 21 (organic anion transporter), member 12
    solute carrier family 21 member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016354.4 → NP_057438.3  solute carrier organic anion transporter family member 4A1

      See identical proteins and their annotated locations for NP_057438.3

      Status: VALIDATED

      Source sequence(s)
      AB031051, AF205072, AI660559, BC015727, BM846201
      Consensus CDS
      CCDS13501.1
      UniProtKB/Swiss-Prot
      Q96BD0, Q9H4T7, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7
      Related
      ENSP00000217159.1, ENST00000217159.6
      Conserved Domains (3) summary
      cd06174
      Location:106 → 489
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:500 → 555
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:106 → 663
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      62642503..62690740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260203.4 → XP_005260260.1  solute carrier organic anion transporter family member 4A1 isoform X3

      UniProtKB/TrEMBL
      E1P5H9, H0UI88
      Related
      ENSP00000434245.1, ENST00000497209.5
      Conserved Domains (3) summary
      cd06174
      Location:106 → 489
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:500 → 555
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:106 → 663
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    2. XM_011528792.4 → XP_011527094.1  solute carrier organic anion transporter family member 4A1 isoform X1

      Conserved Domains (3) summary
      cd06174
      Location:106 → 489
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:500 → 555
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:106 → 663
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    3. XM_017027827.3 → XP_016883316.1  solute carrier organic anion transporter family member 4A1 isoform X2

    4. XM_047440126.1 → XP_047296082.1  solute carrier organic anion transporter family member 4A1 isoform X4

    RNA

    1. XR_001754251.3 RNA Sequence

    2. XR_007067450.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      64441223..64489475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323385.1 → XP_054179360.1  solute carrier organic anion transporter family member 4A1 isoform X3

    2. XM_054323380.1 → XP_054179355.1  solute carrier organic anion transporter family member 4A1 isoform X1

    3. XM_054323383.1 → XP_054179358.1  solute carrier organic anion transporter family member 4A1 isoform X2

    4. XM_054323387.1 → XP_054179362.1  solute carrier organic anion transporter family member 4A1 isoform X4

    5. XM_054323382.1 → XP_054179357.1  solute carrier organic anion transporter family member 4A1 isoform X5

      UniProtKB/Swiss-Prot
      Q96BD0, Q9H4T7, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7

    6. XM_054323384.1 → XP_054179359.1  solute carrier organic anion transporter family member 4A1 isoform X2

    7. XM_054323386.1 → XP_054179361.1  solute carrier organic anion transporter family member 4A1 isoform X3

    8. XM_054323381.1 → XP_054179356.1  solute carrier organic anion transporter family member 4A1 isoform X1

    RNA

    1. XR_008485252.1 RNA Sequence

    2. XR_008485253.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96BD0.2 GenPept UniProtKB/Swiss-Prot:Q96BD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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