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    NEDD4L NEDD4 like E3 ubiquitin protein ligase [ Canis lupus familiaris (dog) ]

    Gene ID: 476189, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NEDD4Lprovided by VGNC
    Official Full Name
    NEDD4 like E3 ubiquitin protein ligaseprovided by VGNC
    Primary source
    VGNC:VGNC:43721
    See related
    Ensembl:ENSCAFG00845001211
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See NEDD4L in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (17509482..17848443, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (18613069..18951799, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (17733960..18072781, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (17567699..17905982, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (17465765..17804137, complement)

    Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102151902 Neighboring gene alpha kinase 2 Neighboring gene uncharacterized LOC119881373 Neighboring gene microRNA mir-122 Neighboring gene uncharacterized LOC119870720 Neighboring gene uncharacterized LOC119870721 Neighboring gene cell death activator CIDE-3-like Neighboring gene ATPase phospholipid transporting 8B1 Neighboring gene uncharacterized LOC111095132

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elevated intracellular Na(+) and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2. Persaud A, et al. Proc Natl Acad Sci U S A, 2022 Jul 26. PMID 35858421, Free PMC Article
    2. A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. Andersen MN, et al. J Biol Chem, 2013 Dec 27. PMID 24214981, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PI3K-SGK1 pathway stabilizes Kv7.1 surface expression by inhibiting Nedd4-2-dependent endocytosis and thereby demonstrates that Nedd4-2 is a key regulator of Kv7.1 localization and turnover in epithelial cells.
      Title: A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sodium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of sodium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase NEDD4-like
    Names
    neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    XP_005615432.1
    XP_013964260.1
    XP_038321232.1
    XP_038321233.1
    XP_038321234.1
    XP_038321235.1
    XP_038321236.1
    XP_038321237.1
    XP_038321238.1
    XP_038321239.1
    XP_038321240.1
    XP_038321241.1
    XP_038321242.1
    XP_038321243.1
    XP_038321244.1
    XP_038321245.1
    XP_038321246.1
    XP_038321247.1
    XP_038337061.1
    XP_038337142.1
    XP_038337329.1
    XP_038337391.1
    XP_038337459.1
    XP_038337536.1
    XP_038337616.1
    XP_038337702.1
    XP_038337784.1
    XP_038337867.1
    XP_038337940.1
    XP_038337975.1
    XP_038338055.1
    XP_038381833.1
    XP_038381834.1
    XP_038381835.1
    XP_038381836.1
    XP_038381837.1
    XP_038381839.1
    XP_038381840.1
    XP_038381841.1
    XP_038381842.1
    XP_038381843.1
    XP_038381844.1
    XP_038381845.1
    XP_038381846.1
    XP_038381847.1
    XP_038381848.1
    XP_038381850.1
    XP_038446145.1
    XP_038446146.1
    XP_038446147.1
    XP_038446148.1
    XP_038446149.1
    XP_038446150.1
    XP_038446151.1
    XP_038446152.1
    XP_038446153.1
    XP_038446154.1
    XP_038446155.1
    XP_038446156.1
    XP_038446157.1
    XP_038446158.1
    XP_038446159.1
    XP_038446160.1
    XP_038509964.1
    XP_038509965.1
    XP_038509966.1
    XP_038509967.1
    XP_038509968.1
    XP_038509969.1
    XP_038509970.1
    XP_038509971.1
    XP_038509972.1
    XP_038509973.1
    XP_038509974.1
    XP_038509975.1
    XP_038509976.1
    XP_038509977.1
    XP_038509978.1
    XP_038509979.1
    XP_533393.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051805.1 Reference ROS_Cfam_1.0

      Range
      17509482..17848443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038654051.1 → XP_038509979.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

      UniProtKB/TrEMBL
      A0A8P0N3B9
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:320 → 370
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:431 → 760
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:198 → 224
      WW; WW domain

    2. XM_038654048.1 → XP_038509976.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      UniProtKB/TrEMBL
      A0A8P0N3B9
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:386 → 436
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:497 → 826
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:336 → 365
      WW; WW domain

    3. XM_038654044.1 → XP_038509972.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:470 → 520
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:581 → 910
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:308 → 337
      WW; WW domain

    4. XM_038654041.1 → XP_038509969.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:490 → 540
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:601 → 930
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:328 → 357
      WW; WW domain

    5. XM_038654049.1 → XP_038509977.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      UniProtKB/TrEMBL
      A0A8P0N3B9
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:379 → 429
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:490 → 819
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:198 → 224
      WW; WW domain

    6. XM_038654045.1 → XP_038509973.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      A0A8P0N3B9
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:445 → 495
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:556 → 885
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:395 → 424
      WW; WW domain

    7. XM_038654040.1 → XP_038509968.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Related
      ENSCAFP00845002063.1, ENSCAFT00845002593.1
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:529 → 561
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:622 → 951
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:367 → 396
      WW; WW domain

    8. XM_038654038.1 → XP_038509966.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Conserved Domains (5) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:529 → 579
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:640 → 969
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:480 → 510
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:367 → 396
      WW; WW domain

    9. XM_038654037.1 → XP_038509965.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

      UniProtKB/TrEMBL
      A0A8C0QPQ7, A0A8P0NUS4
      Related
      ENSCAFP00845002032.1, ENSCAFT00845002554.1
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 581
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:642 → 971
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:387 → 416
      WW; WW domain

    10. XM_038654036.1 → XP_038509964.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 599
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:660 → 989
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:387 → 416
      WW; WW domain

    11. XM_038654047.1 → XP_038509975.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    12. XM_038654043.1 → XP_038509971.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:473 → 523
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:584 → 913
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:311 → 340
      WW; WW domain
      cl14603
      Location:24 → 77
      C2; C2 domain

    13. XM_038654042.1 → XP_038509970.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:473 → 523
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:584 → 913
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:311 → 340
      WW; WW domain
      cl14603
      Location:24 → 77
      C2; C2 domain

    14. XM_038654050.1 → XP_038509978.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    15. XM_038654039.1 → XP_038509967.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

      UniProtKB/TrEMBL
      A0A8P0T5P8
      Conserved Domains (4) summary
      cd04033
      Location:8 → 120
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:516 → 566
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:627 → 956
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:354 → 383
      WW; WW domain

    16. XM_038654046.1 → XP_038509974.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049261.1 Alternate UMICH_Zoey_3.1

      Range
      17567699..17905982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038465319.1 → XP_038321247.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:320 → 370
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:431 → 760
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:198 → 224
      WW; WW domain

    2. XM_038465316.1 → XP_038321244.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:386 → 436
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:497 → 826
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:336 → 365
      WW; WW domain

    3. XM_038465312.1 → XP_038321240.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:470 → 520
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:581 → 910
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:308 → 337
      WW; WW domain

    4. XM_038465309.1 → XP_038321237.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:490 → 540
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:601 → 930
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:328 → 357
      WW; WW domain

    5. XM_038465317.1 → XP_038321245.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:379 → 429
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:490 → 819
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:198 → 224
      WW; WW domain

    6. XM_038465313.1 → XP_038321241.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:445 → 495
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:556 → 885
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:395 → 424
      WW; WW domain

    7. XM_038465308.1 → XP_038321236.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:529 → 561
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:622 → 951
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:367 → 396
      WW; WW domain

    8. XM_038465306.1 → XP_038321234.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

      Conserved Domains (5) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:529 → 579
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:640 → 969
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:480 → 510
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:367 → 396
      WW; WW domain

    9. XM_038465305.1 → XP_038321233.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 581
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:642 → 971
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:387 → 416
      WW; WW domain

    10. XM_038465304.1 → XP_038321232.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 599
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:660 → 989
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:387 → 416
      WW; WW domain

    11. XM_038465315.1 → XP_038321243.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    12. XM_038465311.1 → XP_038321239.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      Conserved Domains (4) summary
      smart00456
      Location:473 → 523
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:584 → 913
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:311 → 340
      WW; WW domain
      cl14603
      Location:24 → 77
      C2; C2 domain

    13. XM_038465310.1 → XP_038321238.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      Conserved Domains (4) summary
      smart00456
      Location:473 → 523
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:584 → 913
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:311 → 340
      WW; WW domain
      cl14603
      Location:24 → 77
      C2; C2 domain

    14. XM_038465318.1 → XP_038321246.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    15. XM_038465307.1 → XP_038321235.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

      Conserved Domains (4) summary
      cd04033
      Location:8 → 120
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:516 → 566
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:627 → 956
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:354 → 383
      WW; WW domain

    16. XM_038465314.1 → XP_038321242.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

      Range
      17465765..17804137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038590232.1 → XP_038446160.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:320 → 370
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:431 → 760
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:198 → 224
      WW; WW domain

    2. XM_038590229.1 → XP_038446157.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:386 → 436
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:497 → 826
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:336 → 365
      WW; WW domain

    3. XM_038590225.1 → XP_038446153.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:470 → 520
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:581 → 910
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:308 → 337
      WW; WW domain

    4. XM_038590222.1 → XP_038446150.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:490 → 540
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:601 → 930
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:328 → 357
      WW; WW domain

    5. XM_038590230.1 → XP_038446158.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:379 → 429
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:490 → 819
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:198 → 224
      WW; WW domain

    6. XM_038590226.1 → XP_038446154.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:445 → 495
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:556 → 885
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:395 → 424
      WW; WW domain

    7. XM_038590221.1 → XP_038446149.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:529 → 561
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:622 → 951
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:367 → 396
      WW; WW domain

    8. XM_038590219.1 → XP_038446147.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

      Conserved Domains (5) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:529 → 579
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:640 → 969
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:480 → 510
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:367 → 396
      WW; WW domain

    9. XM_038590218.1 → XP_038446146.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 581
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:642 → 971
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:387 → 416
      WW; WW domain

    10. XM_038590217.1 → XP_038446145.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 599
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:660 → 989
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:387 → 416
      WW; WW domain

    11. XM_038590228.1 → XP_038446156.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    12. XM_038590224.1 → XP_038446152.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      Conserved Domains (4) summary
      smart00456
      Location:473 → 523
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:584 → 913
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:311 → 340
      WW; WW domain
      cl14603
      Location:24 → 77
      C2; C2 domain

    13. XM_038590223.1 → XP_038446151.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      Conserved Domains (4) summary
      smart00456
      Location:473 → 523
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:584 → 913
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:311 → 340
      WW; WW domain
      cl14603
      Location:24 → 77
      C2; C2 domain

    14. XM_038590231.1 → XP_038446159.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    15. XM_038590220.1 → XP_038446148.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

      Conserved Domains (4) summary
      cd04033
      Location:8 → 120
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:516 → 566
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:627 → 956
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:354 → 383
      WW; WW domain

    16. XM_038590227.1 → XP_038446155.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

      Range
      17733960..18072781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038525922.1 → XP_038381850.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

      UniProtKB/TrEMBL
      A0A8P0N3B9
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:320 → 370
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:431 → 760
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:198 → 224
      WW; WW domain

    2. XM_038525918.1 → XP_038381846.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      UniProtKB/TrEMBL
      A0A8P0N3B9
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:386 → 436
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:497 → 826
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:336 → 365
      WW; WW domain

    3. XM_038525914.1 → XP_038381842.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:470 → 520
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:581 → 910
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:308 → 337
      WW; WW domain

    4. XM_038525911.1 → XP_038381839.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:490 → 540
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:601 → 930
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:328 → 357
      WW; WW domain

    5. XM_038525919.1 → XP_038381847.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      UniProtKB/TrEMBL
      A0A8P0N3B9
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:379 → 429
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:490 → 819
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:198 → 224
      WW; WW domain

    6. XM_038525915.1 → XP_038381843.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      A0A8P0N3B9
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:445 → 495
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:556 → 885
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:395 → 424
      WW; WW domain

    7. XM_038525909.1 → XP_038381837.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:529 → 561
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:622 → 951
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:367 → 396
      WW; WW domain

    8. XM_038525907.1 → XP_038381835.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Conserved Domains (5) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:529 → 579
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:640 → 969
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:480 → 510
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:367 → 396
      WW; WW domain

    9. XM_038525906.1 → XP_038381834.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

      UniProtKB/TrEMBL
      A0A8C0QPQ7, A0A8P0NUS4
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 581
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:642 → 971
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:387 → 416
      WW; WW domain

    10. XM_038525905.1 → XP_038381833.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 599
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:660 → 989
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:387 → 416
      WW; WW domain

    11. XM_038525917.1 → XP_038381845.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    12. XM_038525913.1 → XP_038381841.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:473 → 523
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:584 → 913
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:311 → 340
      WW; WW domain
      cl14603
      Location:24 → 77
      C2; C2 domain

    13. XM_038525912.1 → XP_038381840.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:473 → 523
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:584 → 913
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:311 → 340
      WW; WW domain
      cl14603
      Location:24 → 77
      C2; C2 domain

    14. XM_038525920.1 → XP_038381848.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    15. XM_038525908.1 → XP_038381836.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

      UniProtKB/TrEMBL
      A0A8P0T5P8
      Conserved Domains (4) summary
      cd04033
      Location:8 → 120
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:516 → 566
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:627 → 956
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:354 → 383
      WW; WW domain

    16. XM_038525916.1 → XP_038381844.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      18613069..18951799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038481214.1 → XP_038337142.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

      UniProtKB/TrEMBL
      A0A8P0NUS4
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 599
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:660 → 989
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:387 → 416
      WW; WW domain

    2. XM_038482012.1 → XP_038337940.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    3. XM_038481608.1 → XP_038337536.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:473 → 523
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:584 → 913
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:311 → 340
      WW; WW domain
      cl14603
      Location:24 → 77
      C2; C2 domain

    4. XM_038482127.1 → XP_038338055.1  E3 ubiquitin-protein ligase NEDD4-like isoform X22

      Conserved Domains (4) summary
      smart00456
      Location:199 → 249
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:310 → 639
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:77 → 103
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    5. XM_038481856.1 → XP_038337784.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      Conserved Domains (4) summary
      smart00456
      Location:265 → 315
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:376 → 705
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:215 → 244
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    6. XM_038481463.1 → XP_038337391.1  E3 ubiquitin-protein ligase NEDD4-like isoform X18

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:349 → 399
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:460 → 789
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:187 → 216
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    7. XM_038481401.1 → XP_038337329.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:369 → 419
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:480 → 809
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:207 → 236
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    8. XM_038481939.1 → XP_038337867.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

      Conserved Domains (4) summary
      smart00456
      Location:258 → 308
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:369 → 698
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:77 → 103
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    9. XM_038481688.1 → XP_038337616.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

      UniProtKB/TrEMBL
      A0A8P0N3B9
      Conserved Domains (4) summary
      smart00456
      Location:324 → 374
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:435 → 764
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:274 → 303
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    10. XM_005615375.3 → XP_005615432.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:408 → 440
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:501 → 830
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:246 → 275
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    11. XM_038481133.1 → XP_038337061.1  E3 ubiquitin-protein ligase NEDD4-like isoform X15

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:408 → 458
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:519 → 848
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:246 → 275
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    12. XM_533393.6 → XP_533393.3  E3 ubiquitin-protein ligase NEDD4-like isoform X14

      UniProtKB/TrEMBL
      A0A8C0R4N7, A0A8P0NPV6
      Conserved Domains (4) summary
      smart00456
      Location:428 → 460
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:521 → 850
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    13. XM_038481531.1 → XP_038337459.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:473 → 523
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:584 → 913
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:311 → 340
      WW; WW domain
      cl14603
      Location:24 → 77
      C2; C2 domain

    14. XM_038482047.1 → XP_038337975.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    15. XM_014108785.3 → XP_013964260.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

      UniProtKB/TrEMBL
      A0A8P0T5P8
      Conserved Domains (4) summary
      cd04033
      Location:8 → 120
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:516 → 566
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:627 → 956
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:354 → 383
      WW; WW domain

    16. XM_038481774.1 → XP_038337702.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      A0A8C0R4N7
      Conserved Domains (4) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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