Wdr13 WD repeat domain 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr13provided by MGI
Official Full Name: WD repeat domain 13provided by MGI
Primary source: MGI:MGI:1914661
See related: Ensembl:ENSMUSG00000031166 AllianceGenome:MGI:1914661
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mMg21; DXHXS7467e; 1700060B08Rik; 5730411P10Rik
Summary: Enables promoter-specific chromatin binding activity. Acts upstream of or within negative regulation of type B pancreatic cell proliferation. Predicted to be located in centriolar satellite; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Is expressed in central nervous system and retina. Orthologous to human WDR13 (WD repeat domain 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 49.2), frontal lobe adult (RPKM 36.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.67 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7989540..7999134, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (8123301..8132858, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia.
Title: Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia.
Wdr13(-/0) mice exhibited higher serum insulin levels, better glucose clearance and significantly higher number of proliferating beta-cells; reiterating the finding that absence of WDR13 helps in beta-cell hyper-proliferation and recovery from diabetes
Title: Wdr13 and streptozotocin-induced diabetes.
Results provide evidence that WDR13 is a novel transcriptional activator of AP1 target genes in the presence of JNK signal. The lack of Wdr13 gene conferred protection to a large extent against colitis-induced colorectal tumor in mice through reduced expression of AP1 target genes.
Title: WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and modulates intestinal homeostasis in mice.
Using two types of heterozygous females carrying either maternally and paternally derived mutant Wdr13 allele we provide genetic evidence that development of placenta determines body weight of mice for the entire life.
Title: Role of mouse Wdr13 in placental growth; a genetic evidence for lifetime body weight determination by placenta during development.
WDR13 is a novel negative regulator of the pancreatic beta cell proliferation.
Title: Lack of Wdr13 gene in mice leads to enhanced pancreatic beta cell proliferation, hyperinsulinemia and mild obesity.
WDR13 is localized to the locus XA1.1 and is predominantly expressed in the testis.
Title: A mouse gene encoding a novel member of the WD family of proteins is highly conserved and predominantly expressed in the testis (Wdr13).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125294 (e-PCR)
- UniSTS:162116

MARC_26104-26105:1032794768:1 (e-PCR)
- UniSTS:268940

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables promoter-specific chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of type B pancreatic cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WD repeat-containing protein 13

Names: memory-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290783.1 → NP_001277712.1 WD repeat-containing protein 13 isoform 2

See identical proteins and their annotated locations for NP_001277712.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AL663032, BC057366, BC080853

Consensus CDS

CCDS72338.1

UniProtKB/TrEMBL

Q8K412, Q9CYL7, S4R225

Conserved Domains (2) summary

COG2319
Location:73 → 393

WD40; WD40 repeat [General function prediction only]

sd00039
Location:129 → 165

7WD40; WD40 repeat [structural motif]
NM_026137.5 → NP_080413.2 WD repeat-containing protein 13 isoform 1

See identical proteins and their annotated locations for NP_080413.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK017549, AL663032, BC057366, BC080853

Consensus CDS

CCDS29986.1

UniProtKB/Swiss-Prot

Q91V09

UniProtKB/TrEMBL

Q32P16, Q8K412, Q9CYL7

Related

ENSMUSP00000033506.7, ENSMUST00000033506.13

Conserved Domains (2) summary

COG2319
Location:165 → 485

WD40; WD40 repeat [General function prediction only]

sd00039
Location:221 → 257

7WD40; WD40 repeat [structural motif]
NM_028542.1 → NP_082818.1 WD repeat-containing protein 13 isoform 2

See identical proteins and their annotated locations for NP_082818.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AK006837, AL663032, BC057366, BC080853, CF739215

Consensus CDS

CCDS72338.1

UniProtKB/TrEMBL

Q8K412, Q9CYL7, S4R225

Related

ENSMUSP00000138468.2, ENSMUST00000130832.8

Conserved Domains (2) summary

COG2319
Location:73 → 393

WD40; WD40 repeat [General function prediction only]

sd00039
Location:129 → 165

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

7989540..7999134 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527703.4 → XP_006527766.1 WD repeat-containing protein 13 isoform X1

See identical proteins and their annotated locations for XP_006527766.1

UniProtKB/Swiss-Prot

Q91V09

UniProtKB/TrEMBL

Q32P16, Q8K412, Q9CYL7

Related

ENSMUSP00000111286.2, ENSMUST00000115623.8

Conserved Domains (2) summary

COG2319
Location:165 → 485

WD40; WD40 repeat [General function prediction only]

sd00039
Location:221 → 257

7WD40; WD40 repeat [structural motif]
XM_036162112.1 → XP_036018005.1 WD repeat-containing protein 13 isoform X3

Conserved Domains (2) summary

COG2319
Location:43 → 363

WD40; WD40 repeat [General function prediction only]

sd00039
Location:99 → 135

7WD40; WD40 repeat [structural motif]
XM_036162110.1 → XP_036018003.1 WD repeat-containing protein 13 isoform X1

UniProtKB/Swiss-Prot

Q91V09

UniProtKB/TrEMBL

Q32P16, Q8K412, Q9CYL7

Conserved Domains (2) summary

COG2319
Location:165 → 485

WD40; WD40 repeat [General function prediction only]

sd00039
Location:221 → 257

7WD40; WD40 repeat [structural motif]
XM_036162111.1 → XP_036018004.1 WD repeat-containing protein 13 isoform X2

UniProtKB/TrEMBL

Q8K412, Q9CYL7, S4R225

Conserved Domains (2) summary

COG2319
Location:73 → 393

WD40; WD40 repeat [General function prediction only]

sd00039
Location:129 → 165

7WD40; WD40 repeat [structural motif]