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    DCAF10 DDB1 and CUL4 associated factor 10 [ Homo sapiens (human) ]

    Gene ID: 79269, updated on 5-Mar-2024

    Summary

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    Official Symbol
    DCAF10provided by HGNC
    Official Full Name
    DDB1 and CUL4 associated factor 10provided by HGNC
    Primary source
    HGNC:HGNC:23686
    See related
    Ensembl:ENSG00000122741 MIM:620295; AllianceGenome:HGNC:23686
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WDR32
    Summary
    Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 6.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9p13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (37800554..37867664)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (37824285..37891574)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37800551..37867661)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr9:37753712-37753946 Neighboring gene tRNA methyltransferase 10B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28402 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:37784801-37785316 Neighboring gene uncharacterized LOC105376037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:37800323-37800924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28404 Neighboring gene exosome component 3 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 5 Neighboring gene solute carrier family 25 member 51 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19914 Neighboring gene thioredoxin related transmembrane protein 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:37923197-37923808 Neighboring gene RNA, U7 small nuclear 124 pseudogene Neighboring gene SH2 domain containing adaptor protein B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. Luo Q, et al. Adv Sci (Weinh), 2021 Apr. PMID 33898171, Free PMC Article
    2. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. Lignitto L, et al. Cell, 2019 Jul 11. PMID 31257023, Free PMC Article
    3. CRL4(AMBRA1) is a master regulator of D-type cyclins. Simoneschi D, et al. Nature, 2021 Apr. PMID 33854235, Free PMC Article
    4. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Angers S, et al. Nature, 2006 Oct 5. PMID 16964240
    5. PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network. Reichermeier KM, et al. Mol Cell, 2020 Mar 5. PMID 31973889

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress.
      Title: Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23201, MGC10765, MGC131781

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 10
    Names
    WD repeat domain 32
    WD repeat-containing protein 32

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286810.2 → NP_001273739.1  DDB1- and CUL4-associated factor 10 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK309712, AL138752, BC108686, CB045943
      Consensus CDS
      CCDS75835.1
      UniProtKB/TrEMBL
      A0A0A0MQT4
      Related
      ENSP00000242323.8, ENST00000242323.8
      Conserved Domains (2) summary
      sd00039
      Location:2 → 34
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:9 → 146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_024345.5 → NP_077321.3  DDB1- and CUL4-associated factor 10 isoform a

      See identical proteins and their annotated locations for NP_077321.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL138752, BC108686, CB045943, HY015327
      Consensus CDS
      CCDS6613.2
      UniProtKB/Swiss-Prot
      A4VCJ5, Q32NE2, Q5QP82, Q8N2Q5, Q96ET5, Q9BTQ5, Q9H5P6
      Related
      ENSP00000366953.3, ENST00000377724.8
      Conserved Domains (4) summary
      smart00320
      Location:517 → 555
      WD40; WD40 repeats
      COG2319
      Location:171 → 334
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:172 → 207
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:164 → 319
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      37800554..37867664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423865.1 → XP_047279821.1  DDB1- and CUL4-associated factor 10 isoform X5

    2. XM_047423866.1 → XP_047279822.1  DDB1- and CUL4-associated factor 10 isoform X6

    3. XM_005251577.5 → XP_005251634.1  DDB1- and CUL4-associated factor 10 isoform X1

      UniProtKB/Swiss-Prot
      Q5QP82
      Conserved Domains (3) summary
      COG2319
      Location:169 → 518
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:172 → 207
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:169 → 519
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_005251578.5 → XP_005251635.1  DDB1- and CUL4-associated factor 10 isoform X2

      Conserved Domains (3) summary
      smart00320
      Location:451 → 489
      WD40; WD40 repeats
      COG2319
      Location:169 → 489
      WD40; WD40 repeat [General function prediction only]
      cl02567
      Location:164 → 223
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_017015128.2 → XP_016870617.1  DDB1- and CUL4-associated factor 10 isoform X3

    6. XM_047423864.1 → XP_047279820.1  DDB1- and CUL4-associated factor 10 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      37824285..37891574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363790.1 → XP_054219765.1  DDB1- and CUL4-associated factor 10 isoform X5

    2. XM_054363791.1 → XP_054219766.1  DDB1- and CUL4-associated factor 10 isoform X6

    3. XM_054363786.1 → XP_054219761.1  DDB1- and CUL4-associated factor 10 isoform X1

    4. XM_054363787.1 → XP_054219762.1  DDB1- and CUL4-associated factor 10 isoform X2

    5. XM_054363788.1 → XP_054219763.1  DDB1- and CUL4-associated factor 10 isoform X3

    6. XM_054363789.1 → XP_054219764.1  DDB1- and CUL4-associated factor 10 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5QP82.1 GenPept UniProtKB/Swiss-Prot:Q5QP82

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