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    TMPRSS13 transmembrane serine protease 13 [ Homo sapiens (human) ]

    Gene ID: 84000, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TMPRSS13provided by HGNC
    Official Full Name
    transmembrane serine protease 13provided by HGNC
    Primary source
    HGNC:HGNC:29808
    See related
    Ensembl:ENSG00000137747 MIM:610050; AllianceGenome:HGNC:29808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSP; MSPL; MSPS; TMPRSS11
    Summary
    This gene encodes a member of the type II transmembrane serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
    Expression
    Biased expression in skin (RPKM 9.7), esophagus (RPKM 3.1) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11q23.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (117900641..117929402, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (117917034..117945793, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (117771356..117800117, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117690567-117691301 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117692983-117693536 Neighboring gene FXYD6-FXYD2 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117695199-117695752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117695753-117696305 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:117712427-117713626 Neighboring gene FXYD6 antisense RNA 1 Neighboring gene FXYD domain containing ion transport regulator 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117726457-117726957 Neighboring gene FXYD domain containing ion transport regulator 6 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:117738498-117739697 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:117740007-117740526 Neighboring gene Sharpr-MPRA regulatory region 1172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117778029-117778529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117784655-117785647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117802800-117803339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117803340-117803878 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19102 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:117843533-117843947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5580 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117869597-117870098 Neighboring gene interleukin 10 receptor subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117881450-117881950 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19207 Neighboring gene small integral membrane protein 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117935307-117935808 Neighboring gene RNA, 7SL, cytoplasmic 828, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization. Martin CE, et al. J Biol Chem, 2021 Oct. PMID 34562451, Free PMC Article
    2. Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza. Ohno A, et al. Life Sci Alliance, 2021 Jun. PMID 33820827, Free PMC Article
    3. TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer. Varela FA, et al. Sci Rep, 2020 Aug 17. PMID 32807808, Free PMC Article
    4. Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication. Okumura Y, et al. J Virol, 2010 May. PMID 20219906, Free PMC Article
    5. MSPL/TMPRSS13. Kido H, et al. Front Biosci, 2008 Jan 1. PMID 17981585

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike.
      Title: IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike.
    2. Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization.
      Title: Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization.
    3. Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza.
      Title: Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza.
    4. TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein.
      Title: TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein.
    5. The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy.
      Title: The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy.
    6. TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer.
      Title: TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer.
    7. The data provide novel insight into the cellular properties of TMPRSS13 and highlight phosphorylation of TMPRSS13 as a novel post-translational modification of this TTSP family member and potentially other members of this family of proteases.
      Title: Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization.
    8. study demonstrates that two cellular serine proteases, DESC1 and MSPL, activate influenza viruses and emerging coronaviruses in cell culture and, because of their expression in human lung tissue, might promote viral spread in the infected host
      Title: DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.
    9. results suggest that TMPRSS13 functions as an HGF-converting protease, the activity of which may be regulated by HAI-1
      Title: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.
    10. The authors report that serine proteases, MSPL and its splice variant TMPRSS13, are novel candidates for proteases processing HA proteins of highly pathogenic avian influenza (HPAI) viruses.
      Title: Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in blood microparticle HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protease serine 13
    Names
    membrane-type mosaic serine protease
    transmembrane protease, serine 11
    transmembrane protease, serine 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030336.1 RefSeqGene

      Range
      5052..33813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001077263.3 → NP_001070731.1  transmembrane protease serine 13 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AP002962, AW014913, BC114928
      Consensus CDS
      CCDS41721.1
      UniProtKB/Swiss-Prot
      B4DTM9, E9PIJ5, E9PRA0, F8WAJ3, J3KQC6, Q1RMF8, Q86YM4, Q96JY8, Q9BYE1, Q9BYE2
      Related
      ENSP00000434279.1, ENST00000524993.6
      Conserved Domains (4) summary
      smart00020
      Location:325 → 554
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:326 → 557
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12446
      Location:16 → 87
      DUF3682; Protein of unknown function (DUF3682)
      pfam15494
      Location:231 → 320
      SRCR_2; Scavenger receptor cysteine-rich domain

    2. NM_001206789.2 → NP_001193718.1  transmembrane protease serine 13 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AP002962
      Consensus CDS
      CCDS55788.1
      UniProtKB/Swiss-Prot
      B4DTM9, E9PIJ5, E9PRA0, F8WAJ3, J3KQC6, Q1RMF8, Q86YM4, Q96JY8, Q9BYE1, Q9BYE2
      Related
      ENSP00000435813.1, ENST00000528626.5
      Conserved Domains (4) summary
      smart00020
      Location:290 → 519
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:291 → 522
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:196 → 285
      SRCR_2; Scavenger receptor cysteine-rich domain
      pfam15772
      Location:8 → 87
      UPF0688; UPF0688 family

    3. NM_001206790.2 → NP_001193719.1  transmembrane protease serine 13 isoform 3

      See identical proteins and their annotated locations for NP_001193719.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AP002962
      Consensus CDS
      CCDS55789.1
      UniProtKB/Swiss-Prot
      Q9BYE2
      Related
      ENSP00000436502.1, ENST00000526090.1
      Conserved Domains (5) summary
      smart00020
      Location:325 → 441
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:210 → 226
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam15494
      Location:231 → 320
      SRCR_2; Scavenger receptor cysteine-rich domain
      pfam15772
      Location:8 → 87
      UPF0688; UPF0688 family
      cl21584
      Location:326 → 427
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. NM_001244995.2 → NP_001231924.1  transmembrane protease serine 13 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK027798, AP002962, AY190317, DC381405
      Consensus CDS
      CCDS58185.1
      UniProtKB/Swiss-Prot
      B4DTM9, E9PIJ5, E9PRA0, F8WAJ3, J3KQC6, Q1RMF8, Q86YM4, Q96JY8, Q9BYE1, Q9BYE2
      Related
      ENSP00000387702.2, ENST00000430170.6
      Conserved Domains (4) summary
      smart00020
      Location:325 → 554
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:326 → 557
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:231 → 320
      SRCR_2; Scavenger receptor cysteine-rich domain
      pfam15772
      Location:8 → 87
      UPF0688; UPF0688 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      117900641..117929402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      117917034..117945793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032046.1: Suppressed sequence

      Description
      NM_032046.1: This RefSeq was temporarily suppressed because currently there are not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BYE2.5 GenPept UniProtKB/Swiss-Prot:Q9BYE2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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