myhz2 myosin, heavy polypeptide 2, fast muscle specific [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myhz2provided by ZNC
Official Full Name: myosin, heavy polypeptide 2, fast muscle specificprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020604-1
See related: Ensembl:ENSDARG00000012944 AllianceGenome:ZFIN:ZDB-GENE-020604-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb38
Summary: Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Acts upstream of or within embryonic skeletal system development; response to activity; and skeletal muscle fiber development. Predicted to be part of myosin complex. Is expressed in fin; musculature system; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; disease of cellular proliferation; and distal arthrogryposis (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH4 (myosin heavy chain 4); and MYH8 (myosin heavy chain 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (32206319..32217581)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (31606213..31617426)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myhz2 MHC mRNA was expressed in most cranial muscle elements, pectoral fin muscles, and the tail muscle region of 3-day-old hatching larvae
Title: Myosin heavy chain expression in cranial, pectoral fin, and tail muscle regions of zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

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Markers

AI437080 (e-PCR)
- UniSTS:206592

AI641477 (e-PCR)
- UniSTS:206112

fi38g05.x1 (e-PCR)
- UniSTS:197430

fi17f08.x1 (e-PCR)
- UniSTS:196933

fb26f12 (e-PCR)
- UniSTS:189003

h56846 (e-PCR)
- UniSTS:186965

fd14a01.x1 (e-PCR)
- UniSTS:204157

fb54g09.y1 (e-PCR)
- UniSTS:190714

aa566396 (e-PCR)
- UniSTS:186878

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin, heavy polypeptide 2, fast muscle specific

Names: fmyhc2.1; myo2hc2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152982.2 → NP_694514.2 myosin, heavy polypeptide 2, fast muscle specific

See identical proteins and their annotated locations for NP_694514.2

Status: PROVISIONAL

Source sequence(s)

BC071279

UniProtKB/TrEMBL

A0A8M1P7R3, Q6IQX1

Related

ENSDARP00000051360.5, ENSDART00000051361.6

Conserved Domains (7) summary

cd01377
Location:101 → 768

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:89 → 768

Myosin_head; Myosin head (motor domain)

pfam01576
Location:882 → 1925

Myosin_tail_1; Myosin tail

pfam02736
Location:36 → 74

Myosin_N; Myosin N-terminal SH3-like domain

cl00459
Location:1297 → 1409

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl02488
Location:881 → 1043

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl23720
Location:1002 → 1096

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

32206319..32217581

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171786.4 → XP_005171843.1 myosin, heavy polypeptide 2, fast muscle specific isoform X1

See identical proteins and their annotated locations for XP_005171843.1

UniProtKB/TrEMBL

A0A8M1P7R3, Q6IQX1

Related

ENSDARP00000108224.2, ENSDART00000126873.4

Conserved Domains (7) summary

cd01377
Location:101 → 768

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:89 → 768

Myosin_head; Myosin head (motor domain)

pfam01576
Location:882 → 1925

Myosin_tail_1; Myosin tail

pfam02736
Location:36 → 74

Myosin_N; Myosin N-terminal SH3-like domain

cl00459
Location:1297 → 1409

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl02488
Location:881 → 1043

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl23720
Location:1002 → 1096

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)