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    ZFP91-CNTF ZFP91-CNTF readthrough (NMD candidate) [ Homo sapiens (human) ]

    Gene ID: 386607, updated on 10-Oct-2023

    Summary

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    Official Symbol
    ZFP91-CNTFprovided by HGNC
    Official Full Name
    ZFP91-CNTF readthrough (NMD candidate)provided by HGNC
    Primary source
    HGNC:HGNC:33441
    See related
    AllianceGenome:HGNC:33441
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFP91; ZNF757; Zfp-91
    Summary
    This gene represents a read-through transcript composed of ZFP91 and CNTF sequence. This transcript is thought to be non-coding because it would be subject to nonsense-mediated mRNA decay (NMD). Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Aug 2008]
    Expression
    Broad expression in testis (RPKM 34.3), bone marrow (RPKM 11.6) and 24 other tissues See more
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    Genomic context

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    Location:
    11q12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (58579114..58625733)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (58528621..58575231)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58346587..58393206)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369313 Neighboring gene Sharpr-MPRA regulatory region 15251 Neighboring gene olfactory receptor family 5 subfamily B member 21 Neighboring gene leupaxin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4736 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58345528-58346220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4737 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:58346914-58347605 Neighboring gene ZFP91 zinc finger protein, atypical E3 ubiquitin ligase Neighboring gene NANOG hESC enhancer GRCh37_chr11:58419172-58419673 Neighboring gene ciliary neurotrophic factor Neighboring gene NANOG hESC enhancer GRCh37_chr11:58420305-58420859 Neighboring gene glycine-N-acyltransferase Neighboring gene glycine-N-acyltransferase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. Lam A, et al. Gene, 1991 Jun 30. PMID 1840538
    2. Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. Unoki M, et al. Int J Oncol, 2003 Jun. PMID 12738986
    3. Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing. Hiller M, et al. Am J Hum Genet, 2006 Feb. PMID 16400609, Free PMC Article
    4. Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs. Grottke C, et al. Int J Cancer, 2000 Nov 15. PMID 11058868
    5. Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Vijai J, et al. PLoS Genet, 2013. PMID 23349640, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ZFP91-CNTF

    Included genes: CNTF, ZFP91

    Other Names

    • E3 ubiquitin-protein ligase ZFP91
    • RING-type E3 ubiquitin transferase ZFP91
    • ZFP91-CNTF readthrough (non-protein coding)
    • Zinc finger protein 757
    • zinc finger protein 91 homolog, ciliary neurotrophic factor transcription unit

    Clone Names

    • MGC51126

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024091.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AB057443, AP001350, BG721319

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      58579114..58625733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      58528621..58575231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_003104.1: Suppressed sequence

      Description
      NG_003104.1: This RefSeq was permanently suppressed because this region is now thought to be transcribed as a readthrough transcript expressing a fusion protein, rather than co-transcribed.

    2. NM_170768.2: Suppressed sequence

      Description
      NM_170768.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version

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