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Items: 1 to 20 of 894

1.

Gene expression profiling of Calca neurons in the parabrachial nucleus (PBN)

(Submitter supplied) Calca-expressing neurons in the parabrachial nucleus (PBN) play a major role in regulating appetite and transmitting real or potential threat signals. Here, we reveal transcripts specific or highly enriched in this neuronal population by using mouse genetics and a conditional viral ribosome-tagging approach to phenotype these neurons.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
4 Samples
Download data: IDAT, TXT
Series
Accession:
GSE207153
ID:
200207153
2.

Comparative study of transcriptome in the hearts isolated from mice, rats, and human

(Submitter supplied) The heart is a major organ in mammalian life, and the study of transcription factors, particularly those that regulate cardiac rhythm, has been an important focus of science. However, few studies have focused on species differences. Accordingly, challenges remain in studying genes that have universal functions across species and genes that determine species differences. In this study, we reanalyzed mouse, rat, and human transcriptome data obtained from different platforms by calculating specificity measure (SPM) values in consideration of species differences. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
20 Samples
Download data: IDAT
Series
Accession:
GSE200326
ID:
200200326
3.

mRNA expression profile of regulatory neutrophil induced by sodiumtaurodeoxycholate

(Submitter supplied) Conventional strategies for the development of new drugs have used chemical compounds or large molecules that act as an agonist, antagonist, inhibitor (enzyme or signal transducer), enzyme cofactor or supplement for normal constituents in the body. Recently, the field of cell therapeutics has received much attention. Ex vivo expansion and/or manipulation is essential in cell therapy, which might limit the entrance of pharmaceutical companies into the cell therapy market. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE49593
ID:
200049593
4.

Mmp-13 deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number and attenuates the cortical bone loss caused by estrogen deficiency in mice

(Submitter supplied) We generated mice with conditional Mmp-13 deletion in Prrx1 expressing cells (Mmp-13dPrrx1) and compared the effect of estrogen deficiency on their bone phenotype to that of control littermates (Mmp-13f/f)
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
6 Samples
Download data: TXT
Series
Accession:
GSE191214
ID:
200191214
5.

Genome-wide analysis of fasting induced gene expression in the mouse hypothalamus

(Submitter supplied) This study utilized AgRP+/- and AgRP-/- mice either under fed or 30h fasted conditions, to reveal genes that are regulated by fasting and AgRP.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
16 Samples
Download data: IDAT
Series
Accession:
GSE139148
ID:
200139148
6.

Doublecortin mutation leads to persistent defects in the Golgi apparatus and mitochondria in adult hippocampal pyramidal cells

(Submitter supplied) Human doublecortin (DCX) mutations are associated with severe brain malformations leading to aberrant neuron positioning (heterotopia), intellectual disability and epilepsy. DCX is a microtubule-associated protein which plays a key role during neurodevelopment in neuronal migration and differentiation. Dcx knockout (KO) mice show disorganized hippocampal pyramidal neurons. The CA2/CA3 pyramidal cell layer is present as two abnormal layers and disorganized CA3 KO pyramidal neurons are also more excitable than wild-type (WT) cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
14 Samples
Download data: TXT
Series
Accession:
GSE185031
ID:
200185031
7.

Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation

(Submitter supplied) We systemetically distinguished the effects of each class of sex-biasing factors on transcriptome regulation in liver and adipose tissues with the Four Core Genotype (FCG) mouse model. The results offers a tissue-specific account of the individual contribution of major sex-biasing factors to gene regulation.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
115 Samples
Download data: TXT
Series
Accession:
GSE176033
ID:
200176033
8.

A balanced Oct4 protein interaction network is crucial for maintaining pluripotency

(Submitter supplied) Oct4 is considered a master transcription factor for pluripotent cell self-renewal and embryo development. It primarily collaborates with other transcriptional factors or coregulators to maintain pluripotency. However, it is still unclear how Oct4 interacts with its partners. Here, we show that the Oct4 linker interface mediates competing and balanced Oct4 protein interactions which are crucial for maintaining pluripotency. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
10 Samples
Download data: TXT
Series
Accession:
GSE144305
ID:
200144305
9.

Gene expression microarray analysis of whole mouse hamstring muscles to identify genes promoting the devlopment of neurogenic heterotopic ossifications following spinal cord injury

(Submitter supplied) To better understand which genes/pathways are activated in injured muscles following a spinal cord injury (SCI) and how these promote the development of neurogenic heterotopic ossification (NHO), we performed gene expression profiling by microarray of muscles in the early phase following muscle injury.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
16 Samples
Download data: IDAT, TXT
Series
Accession:
GSE165062
ID:
200165062
10.

Renal circadian rhythm dysregulation in lupus nephritis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL21103 GPL6885
117 Samples
Download data: IDAT, TXT
Series
Accession:
GSE131894
ID:
200131894
11.

Renal circadian rhythm dysregulation in lupus nephritis [array]

(Submitter supplied) This study examines the circadian gene expression of whole kidneys of young and nephritic NZB/W F1 mice
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
48 Samples
Download data: IDAT, TXT
Series
Accession:
GSE131892
ID:
200131892
12.

Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice

(Submitter supplied) Chronic stress induces adaptive changes in the brain via the cumulative action of glucocorticoids, which is associated with mood disorders. Here we show that repeated daily five-minute restraint resolves pre-existing stress-induced depressive-like behavior in mice. Repeated injection of glucocorticoids in low doses mimics the anti-depressive effects of short-term stress. Repeated exposure to short-term stress and injection of glucocorticoids activate neurons in largely overlapping regions of the brain, as shown by c-Fos staining, and reverse distinct stress-induced gene expression profiles. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
6 Samples
Download data: TXT, XLSX
Series
Accession:
GSE183624
ID:
200183624
13.

Whole genome profiling of murine lymphocytes and statistical validation of a panel of immune molecules to predict vaccine efficacy against Mycobacterium tuberculosis

(Submitter supplied) Transcriptional profiling of splenic lymphocytes derived from vaccinated mice, and ex-vivo exposed to M.tb.-infected macrophages in culture. Splenocytes from mice innoculated with Mycobacterium bovis BCG Pasteur (PAS), or M. bovis BCG Copenhagen (SSI), or heat killed BCG SSI (HK), or uninfected control, were ex vivo co-cultured with mouse bone marrow macrophages previously infected with M. tb.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
11 Samples
Download data: TXT
Series
Accession:
GSE135592
ID:
200135592
14.

Small intestinal tissue and epithelial regeneration after 12 Gy whole-body irradiation of C57BL/6 wild type mice

(Submitter supplied) C57BL/6 wild type mice were exposed to 12 Gy whole-body irradiation. Before irradiation (t=0) and at t=24, 48 and 96 hours after irradiation, mice (n=10 per time point) were euthanized. From n=5 mice per time point RNA was isolated from small-intestinal (jejunum) tissue, from n=5 mice per time point RNA was isolated from EDTA-isolated epithelial cells from small-intestinal tissue (jejunum).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
40 Samples
Download data: IDAT, TXT
Series
Accession:
GSE179777
ID:
200179777
15.

Genome-wide analysis for joint tissues of Fas (ligand) mutant mice during autoantibody induced arthritis

(Submitter supplied) Analysis on gene expression between RA-induced WT, Fas^lpr/lpr, and Fas^gld/gld mice. Data shows different expression pattern between Fas^gld/gld joint and Fas^lpr/lpr(or WT) mice. The reseults indicate sFasL-dependent, but Fas-independent gene expression during AIA
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
3 Samples
Download data: IDAT
Series
Accession:
GSE110343
ID:
200110343
16.

Hemispheric lateralization of gene expression profile in stressed mice

(Submitter supplied) Chronic stress increases the risk of emotional disorders by altering brain structure and function. Patients with post-traumatic stress disorder (PTSD) or depressions show activity difference between the two hemispheres in the prefrontal cortex (PFC) but molecular targets associated with this laterality remains unclear. Here, we reveal that chronic social defeats later gene-expression profile differentially between the left and right medial prefrontal cortices (mPFC) in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
16 Samples
Download data: TXT
Series
Accession:
GSE114224
ID:
200114224
17.

Regulation of adipocyte differentiation by IRF3

(Submitter supplied) The hypothesis tested is that IRF3 regulates adipogenesis and adipocyte function. Global gene expression of IRF3 wildtype (WT) and knockout (KO) adipocytes at different days during differentiation was compared. The results provide evidence on how IRF3 controls PPARg -regulated adipogenic program thereby regulate adipocyte differentiation.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE172491
ID:
200172491
18.

Gene expression profiling of Vglut2 neurons in the vestibular nucleus (VN)

(Submitter supplied) Vestibular nuclei (VN) are critical for the processing of movement input, and motion-induced activation of VN neurons recapitulates MS-related signs. However, the genetic identity of VN neurons mediating MS-related autonomic and aversive responses remains unknown. Here, we identify diferent markers of glutamatergic vestibular neuronal populations using the RiboTag apparoach.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
6 Samples
Download data: TXT
Series
Accession:
GSE167672
ID:
200167672
19.

Brain Genexpession of a mouse modle of Sepsis-associated encephalopathy (SAE)

(Submitter supplied) Sepsis-associated encephalopathy (SAE) is a major and frequent complication in patients with sepsis resulting in delirium and premature death. Sepsis survivors commonly suffer from long-term cognitive impairment causing immense burden on patients, caregivers, and economic health systems. Underlying pathophysiology of SAE related cognitive deficits is largely unresolved, Thus treatment options are missing. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
16 Samples
Download data: IDAT, TXT
Series
Accession:
GSE167610
ID:
200167610
20.

Genome-wide analysis of genes regulated by AhR

(Submitter supplied) Analysis of gene expression changes due to lack of AhR in NK cells. Cytokine activated NK cells upregulate expression of AhR and display homeostatic and functional defects. Goal of this study was to identify gene expression changes associated with NK cell activity.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE161923
ID:
200161923
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