GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL10669 GPL85

26 Samples

Download data: CEL

(Submitter supplied) We have undertaken the first comprehensive analysis of gene expression influenced by acute LSD administration in the mammalian brain to elucidate the mechanism of action of this class of drugs. We have identified a number of genes that are predicted to be involved in the processes of synaptic plasticity, glutamatergic signaling and cytoskeletal architecture. Understanding these molecular events will lead to new insights into the etiology of disorders whose behavioral symptoms resemble the temporary effects of hallucinogenic drugs, and also may ultimately result in new therapies.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

6 Samples

Download data: CEL

(Submitter supplied) Constrictive vascular remodeling limiting blood flow, as well as compensatory outward remodeling, have been observed in many cardiovascular diseases; however, the underlying mechanisms regulating the remodeling response of the vessels remain unclear. Plasminogen activators (PA) are involved in many of the processes of vascular remodeling. We have shown previously that increased tissue-type PA (tPA) contributes to outward vascular remodeling. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

40 Samples

Download data: CEL

(Submitter supplied) Fatty acids from corn oil for 18 months influence ACI rat prostate gene expression We used microarrays to detail the global alterations of gene expression in the prostate of ACI rats fed high and low corn oil for 18 months

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

6 Samples

Download data: CEL

(Submitter supplied) Chronic alcohol ingestion changes the alveolar landscape. We used microarrays to characterize the change in mRNA expression following chronic alcohol ingestion in male Sprague Dawley rates (EtOH 36% of calories)

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS5049

Platform:

GPL85

7 Samples

Download data: CEL

(Submitter supplied) Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the longstanding hypothesis that chronic GC exposure promotes brain aging/Alzheimer's disease. Here, we adrenalectomized male F344 rats at 15-months-of-age, maintained them for 3 months with implanted corticosterone (CORT) pellets producing low or intermediate (glucocorticoid-receptor (GR)-activating) blood levels of CORT, and performed microarray/pathway analyses in hippocampal CA1. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4757

Platform:

GPL85

39 Samples

Download data: CEL

(Submitter supplied) We have generated a transgenic rat model with postnatal pathology. In order to investigate the potential contribution of changes in kidney gene expression to the pathology, we have conducted microarray-based gene expression profiling of postnatal kidney.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

4 Samples

Download data: CEL, CHP

(Submitter supplied) Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate potential molecular relationships between SD and aging in brain tissue. Here, we tested the hypothesis that young rats exposed to 24 or 72 hour SD would respond with stress and aging-like shifts in brain hippocampal CA1 gene expression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

69 Samples

Download data: CEL

(Submitter supplied) Acute lung inflammation can alter the pulmonary function of susceptible individuals and exacerbate the pathogenesis of chronic inflammatory lung diseases including chronic obstructive pulmonary disease (COPD), cystic fibrosis and asthma. Exposure to lipopolysaccharide (LPS) or endotoxin, a constituent of outer cell membrane of gram negative bacteria, induces airway inflammation that is primarily characterized by increased polymorphonuclear neutrophils (PMNs) at early time points. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4253

Platform:

GPL85

6 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) Most kidney allograft losses are caused by chronic allograft dysfunction (CAD). The aim of the study was to correlate changes in gene expression over time during the development of chronic damage in contrast to13cisRA Treated animal that demonstrated morphologically healthy kidneys by the end of teh study. Renal allografts were harvested from placebo and13cisRA Treatment groups for time points 0d, 7d, 14d and 56d (n=3-5) and examined for steady state mRNA expression using Affymetrix microarray RG-U34A. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

30 Samples

Download data: CEL, TXT

(Submitter supplied) The current study was designed to determine if dietary fatty acid concentration and composition affects the development and progression of nonalcoholic fatty liver disease. Male SD rats were overfed diets low (5%) or high (70%) fat diets via total enteral nutrition where the fat source was olive oil (monounsaturated), or corn oil (polyunsaturated). Overfeeding 5% corn oil produced little steatosis relative to feeding 5% olive oil. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

12 Samples

Download data: CEL

(Submitter supplied) Not all patients with nerve injury develop neuropathic pain. The extent of nerve damage and age at the time of injury are two of the few risk factors identified to date. In addition, preclinical studies show that neuropathic pain variance is heritable. To define such factors further, we performed a large-scale gene profiling experiment which plotted global expression changes in the rat dorsal root ganglion in three peripheral neuropathic pain models. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4625

Platform:

GPL85

56 Samples

Download data: CEL

(Submitter supplied) The objective of this study was to identify genes that are differentially regulated in cultured sympathetic neurons during BMP-induced dendritic growth and to determine the temporal expression patterns of these genes.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3930

Platform:

GPL85

9 Samples

Download data: CEL

(Submitter supplied) During murine hypothalamic development, different neuroendocrine cell phenotypes are generated in overlapping periods; this suggests that cell-type specific developmental programs operate to achieve complete maturation. A balance between programs that include cell proliferation, cell cycle withdrawal as well as epigenetic regulation of gene expression characterizes neurogenesis. Thyrotropin releasing hormone (TRH) is a peptide that regulates energy homeostasis and autonomic responses. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

5 Samples

Download data: CEL, CHP

(Submitter supplied) Fetal and neonatal beta cells have poor glucose-induced insulin secretion and only gain robust glucose responsiveness several weeks after birth. This unresponsiveness may be due to a generalized immaturity of the metabolic pathways normally found in beta cells. Gene expression profile of neonatal (1 day old) and young adult (6 weeks old) Sprague-Dawley rat islets were evaluated and compared.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

7 Samples

Download data: CEL, TXT

(Submitter supplied) Myc is a multifaceted bHLHZip transcription factor deregulated in the majority of human cancers. How to target Myc for cancer therapy is unclear, given its involvement in a variety of key functions in healthy cells. We used microarrays to capture the cellular transcriptional response to Omomyc – a Myc interfering molecule acting at the level of protein protein interactions that demonstrated a remarkable therapeutic efficacy in transgenic mouse cancer models. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

4 Samples

Download data: CEL

(Submitter supplied) Analysis of global gene expression in mesenteric control and collateral arteries was used to investigate potential molecules, pathways and mechanisms responsible for impaired collateral growth in the Spontaneously Hypertensive rat (SHR). A fundamental difference was observed in the overall gene expression pattern in SHR vs. Wistar Kyoto (WKY) collaterals (only 6% of the genes altered in collaterals were similar). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

15 Samples

Download data: CEL, CHP

(Submitter supplied) This study investigates the effects of the aryl hydrocarbon receptor (AhR) ligands TCDD and PCB126 on hepatic gene expression in female sprague dawley rats. Rats were treated with toxicological equivalent doses of TCDD (100ng/kg/day) (Toxic equivalence factor (TEF) = 1.0), PCB126 (30ng, 300ng or 1000ng/kg/day) (TEF = 0.1) or a vehicle control of corn oil:acetone (99:1) 5 days a week for 52 weeks.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

15 Samples

Download data: CEL

(Submitter supplied) Nitric oxide (NO) regulated pulmonary vascular function and structure, in part, via its effect on gene expression. We used microarrays to determine the up- and downregulated genes in rat pulmonary artery smooth muscle cells exposed to the NO donor S-nitrosoglutathione (GSNO) for 1, 2, and 4 hours.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

8 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) With a filter of false-discovery rate less than 0.1 and fold change greater than 1.5, 115 genes were found to be up- and 137 were down-regulated in alveolar macrophages during Pneumocystis carinii infection.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

12 Samples

Download data: CEL, CHP