Similar studies for GEO DataSets (Select 200143385) - GEO DataSets

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Items: 20

Select item 2001433851.

microRNA expression analysis of metastatic adrenocortical tumors

(Submitter supplied) Background: Adrenocortical carcinoma (ACC) is a rare, often-aggressive neoplasm of the adrenal cortex, with a 14.5-month median overall survival. We asked whether tumors from patients with advanced or metastatic ACC would offer clues as to putative genes that might have critical roles in disease progression or in more aggressive disease biology. Methods: We conducted comprehensive genomic and expression analyses, including microRNA profiling, of 33 ACCs and 6 normal adrenals. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL27982
39 Samples

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Series

Accession:: GSE143385

ID:: 200143385

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001433832.

Gene expression analysis of metastatic adrenocortical tumors

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16043
63 Samples

Download data: CEL, CHP

Series

Accession:: GSE143383

ID:: 200143383

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000522963.

SNP data from 76 adrenocortical carcinomas

(Submitter supplied) SNP array data from 76 adrenocortical carcinomas were used to detect recurrent copy number alterations.

Organism:: Homo sapiens

Type:: Genome variation profiling by array

Platform:: GPL17913
76 Samples

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Series

Accession:: GSE52296

ID:: 200052296

Select item 2000492804.

Integrated genomic analyses of adrenocortical tumors (SNP array, DNA methylation, mRNA and miRNA expression).

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by high throughput sequencing; SNP genotyping by SNP array; Methylation profiling by genome tiling array; Genome binding/occupancy profiling by array

6 related Platforms
324 Samples

Download data: CEL

Series

Accession:: GSE49280

ID:: 200049280

Select item 2000492795.

Micro-RNA sequencing from 78 adrenocortical carcinomas

(Submitter supplied) Micro-RNA sequencing of adrenocortical tumors and normal adrenal samples.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11154
78 Samples

Download data: TXT

Series

Accession:: GSE49279

ID:: 200049279

PubMed Similar studies SRA Run Selector

Select item 2000492786.

Expression profiling by array of 44 adrenocortical carcinomas

(Submitter supplied) Gene expression profiles of adrenocortical carcinomas were analyzed using Affymetrix Human Gene 2.0 ST Array to identify homogeneous molecular subgroups

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
44 Samples

Download data: CEL

Series

Accession:: GSE49278

ID:: 200049278

Select item 2000492777.

Genome-scale methylome profiling of adrenocortical carcinomas (ACC) and adenomas (ACA)

(Submitter supplied) Genome-scale DNA methylation was analyzed in a cohort of ACC and ACA to identify DNA methylation changes.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL8490
81 Samples

Download data: TXT

Series

Accession:: GSE49277

ID:: 200049277

Select item 2000492768.

SNP data from 45 adrenocortical carcinomas

(Submitter supplied) SNP array data from 45 adrenocortical carcinomas were used to detect recurrent copy number alterations.

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platforms:: GPL8887 GPL13135
45 Samples

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Series

Accession:: GSE49276

ID:: 200049276

PubMed Similar studies

Select item 2000284769.

Characterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations.

(Submitter supplied) Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors. Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alterations.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3912
Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE28476

ID:: 200028476

Select item 391210.

Adrenocortical adenomas harboring β-catenin gene CTNNB1 mutations

Analysis of adrenocortical adenomas (AA) with β-catenin missense mutations and AAs with wild-type CTNNB1. Mutations of CTNNB1 are common in AA and adrenocortical carcinomas (ACC). Results provide insight into molecular mechanisms deregulated in adrenocortical tumors with CTNNB1 genetic alterations.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 genotype/variation, 3 other, 2 tissue sets

Platform:: GPL570
Series:: GSE28476
8 Samples

Download data: CEL

DataSet

Accession:: GDS3912

ID:: 3912

Select item 20002281611.

Deregulated miRNAs in adrenocortical tumors

(Submitter supplied) We performed miRNA expression profiling in a series of adrenocortical carcinomas, adrenocortical adenomas and normal adreno cortex using a microarray approach. Significant differentially expressed miRNAs among groups were identified using SAM analysis.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL13347
52 Samples

Download data: TXT

Series

Accession:: GSE22816

ID:: 200022816

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003506612.

SNP array profiling of childhood adrenocortical tumours reveals distinct pathways of tumourigenesis and highlights candidate driver genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platforms:: GPL6985 GPL6986 GPL8887
31 Samples

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Series

Accession:: GSE35066

ID:: 200035066

PubMed Similar studies

Select item 20003506413.

SNP data from 12 childhood adrenocortical tumors from outside Brazil

(Submitter supplied) SNP array data from 12 childhood adrenocortical tumors (ACT) were used to identify recurrent chromosome rearrangements and candidate driver genes.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platforms:: GPL6986 GPL8887
12 Samples

Download data: TXT

Series

Accession:: GSE35064

ID:: 200035064

PubMed Similar studies

Select item 20002480414.

SNP data from 13 childhood adrenocortical tumours from Brazilian patients and 6 matched normal samples

(Submitter supplied) SNP array data from 13 Brazilian childhood adrenocortical tumors (ACTs) were analyzed to detect recurrent copy number changes and highlight potential candidate driver genes.

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platforms:: GPL6985 GPL6986
19 Samples

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Series

Accession:: GSE24804

ID:: 200024804

PubMed Full text in PMC Similar studies

Select item 20006135915.

Long noncoding RNAs profiles of adrenocortical carcinomas, adrenocortical adenomas and normal adrenal cortex

(Submitter supplied) Adrenocortical carcinoma (ACC) is an aggressive malignancy with high rates of recurrence following surgical resection. Long noncoding RNAs (lncRNAs) play an important role in cancer development. Pathogenesis of adrenal tumours has been characterised by mRNA, microRNA and methylation expression signatures but it is unknown if this extends to lncRNAs. We sought to describe lncRNA expression signatures in adrenocortical carcinoma (ACC), adrenal cortical adenoma (ACA) and normal adrenal cortex (NAC). more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16956
21 Samples

Download data: TXT

Series

Accession:: GSE61359

ID:: 200061359

Select item 20004327916.

MicroRNA profiling of benign and malignant adrenocortical tumors reveals potential biomarkers of recurrence

(Submitter supplied) MicroRNAs are small, non-coding RNAs that regulate gene expression at post-transcriptional levels. There is increasing evidence to suggest that miRNAs could be useful in cancer diagnosis, prognosis, and therapy. The aim of our study was to identify miRNAs predictors of poor prognosis in adrenocortical cancer. miRNA microarray expression profiling was performed on a cohort of 6 adenomas, 6 non-recurrent carcinomas (Carc_B) and 6 recurrent carcinomas (Carc_A). more...

Organism:: Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Murid gammaherpesvirus 4; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL16452
18 Samples

Download data: TXT

Series

Accession:: GSE43279

ID:: 200043279

Select item 20007602117.

Gene expression profiling of pediatric adrenocortical tumors collected by the International Pediatric Adrenocortical Tumor Registry (IPACTR).

(Submitter supplied) We have previously observed that expression of HLA genes associate with histology of adrenocortical tumors (PMID 17234769). Here, we supplement that data with gene expression data on N additional tumors. This submission includes the data from the original study and N additional tumors.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
29 Samples

Download data: CEL

Series

Accession:: GSE76021

ID:: 200076021

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007601918.

Gene expression profiling of pediatric adrenocortical tumors of patients treated on the Children's Oncology Group XXX protocol.

(Submitter supplied) We have previously observed that expression of HLA genes associate with histology of adrenocortical tumors (PMID 17234769). Here, we used gene expression microarrays to associate the diagnostic tumor expression of these genes with outcome among 34 patients treated on the COG ARAR0332 protocol.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
34 Samples

Download data: CEL

Series

Accession:: GSE76019

ID:: 200076019

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007787119.

Pathway implications of aberrant global methylation in adrenocortical cancer

(Submitter supplied) Context: Adrenocortical carcinomas (ACC) are a rare tumor type with a poor five-year survival rate and limited treatment options. Objective: Understanding of the molecular pathogenesis of this disease has been aided by genomic analyses highlighting alterations in TP53, WNT, and IGF signaling pathways. Further elucidation is needed to reveal therapeutically actionable targets in ACC. Design: In this study, global DNA methylation levels were assessed by the Infinium HumanMethylation450 BeadChip Array on 18 ACC tumors and 6 normal adrenal tissues. more...