GEO DataSets

(Submitter supplied) The present analysis was executed to determine the impact of protein supplementation on changes in the muscle transcriptome following prolonged endurance training

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL28236

80 Samples

Download data: CEL, TXT

(Submitter supplied) In our study, we investigated for contractile activity-specific changes in the transcriptome in untrained and trained (after an aerobic training programme) human skeletal muscle. The second goal was to examine effect of aerobic training on gene expression in muscle at baseline (after long term training). Seven untrained males performed the one-legged knee extension exercise (for 60 min) with the same relative intensity before and after a 2 month aerobic training programme (1 h/day, 5/week). more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16791 GPL18573

84 Samples

Download data: TXT

(Submitter supplied) The aim of this study was to elucidate the transcriptional signatures that distinguish the endurance-trained and the untrained muscle in healthy adult young males, both at baseline as well as in response to an acute bout of exercise.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13667

48 Samples

Download data: CEL

(Submitter supplied) We used gene microarray analysis to compare the global expression profile of genes involved in adaptation to exercise training in skeletal muscle from chronically strength/resistance trained (ST), endurance trained (ET) and untrained control subjects (Con). Resting skeletal muscle samples (~100mg) were obtained from the vastus lateralis of 20 subjects (Con n=7, ET n=7, ST n=6; trained groups >8 years specific training). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6042

21 Samples

Download data: GPR

(Submitter supplied) Impact of protein ingestion following 1 h intense cycling on the induced transcriptome and signaling in biopsy samples from endurance-trained men, relative to isocaloric control

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6104

39 Samples

Download data: TXT

(Submitter supplied) Changes in Gene exporession after 8 weeks of PrimaVie Shilajit Supplementation were measured in vastus lateralis GeneChip® Human Transcriptome Array 2.0 was used to study the gene expression in human vastus lateralis after supplementation of PrimaVie Shilajit and identified distinct classes of up-regulated genes during this process.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17586

6 Samples

Download data: CEL, CHP

(Submitter supplied) Vitamin D deficiency is common among older adults and has been linked to muscle weakness. Vitamin D supplementation has been proposed as a strategy to improve muscle function in older adults. The aim of this study was to investigate the effect of calcifediol (25-hydroxycholecalciferol) on whole genome gene expression in skeletal muscle of vitamin D deficient frail older adults. A double-blind placebo controlled trial was conducted in vitamin D deficient frail older adults (aged above 65), characterized by blood 25-hydroxycholecalciferol concentrations between 20 and 50 nmol/L. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17692

44 Samples

Download data: CEL

(Submitter supplied) Protein-leucine supplement ingestion following strenuous endurance exercise accentuates skeletal-muscle protein synthesis and adaptive molecular responses, but the underlying transcriptome is uncharacterized. In a randomized single-blind triple-crossover design, 12 trained men completed 100 min of high-intensity cycling then ingested either 70/15/180/30g protein/leucine/carbohydrate/fat (15LEU), 23/5/180/30g (5LEU) or 0/0/274/30g (CON) beverages during the first 90 min of a 240-min recovery period. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

72 Samples

Download data: TXT

(Submitter supplied) Exercise is beneficial to human’s health, and many of the effects are mediated by changes in immune function. However, the mechanisms underpinning the immune-regulatory effect of exercise remain unclear. We used microarrays to assess the global gene expression in blood leukocytes in young endurance athletes and non-athlete controls, the differential gene expression between two groups was analzyed using bioinformatic methods and enriched biological processes and pathways were identified for up- and down-regulated genes in athletes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

23 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; synthetic construct

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by array

Platforms:

GPL19117 GPL11154

28 Samples

Download data: CEL, TXT

(Submitter supplied) In a previous study, the whole transcriptome of the vastus lateralis muscle from sedentary elderly and from age-matched athletes with an exceptional record of high-intensity, life-long exercise training was compared, the two groups representing the two ends of a physical activity scale. Exercise training enabled the skeletal muscle to counteract age-related sarcopenia by inducing a wide range of adaptations, sustained by the expression of protein-coding genes involved in energy handling, proteostasis, cytoskeletal organization, inflammation control, and cellular senescence. more...

Organism:

synthetic construct; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL19117

14 Samples

Download data: CEL

(Submitter supplied) In a previous study, the whole transcriptome of the vastus lateralis muscle from sedentary elderly and from age-matched athletes with an exceptional record of high-intensity, life-long exercise training was compared, the two groups representing the two ends of a physical activity scale. Exercise training enabled the skeletal muscle to counteract age-related sarcopenia by inducing a wide range of adaptations, sustained by the expression of protein-coding genes involved in energy handling, proteostasis, cytoskeletal organization, inflammation control, and cellular senescence. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

14 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL9454 GPL570

65 Samples

Download data: CEL

(Submitter supplied) Microgravity has a dramatic impact on human physiology, illustrated in particular with skeletal muscle impairment. A thorough understanding of the mechanisms leading to loss of muscle mass and structural disorders is necessary for the definition of efficient clinical and spaceflight countermeasures. We investigated the effects of long-term bed rest on transcriptome of soleus (SOL) and vastus lateralis (VL) muscles in healthy women (BRC group, n=8), and the potential beneficial impact of protein supplementation (BRN group, n=8) and of a combined resistance and aerobic training (BRE group, n=8). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6398

170 Samples

Download data: GPR

(Submitter supplied) Skeletal muscle adapts to resistance exercise (RE) performance acutely and chronically. An important regulatory step of muscle adaptation to RE is gene expression. Microarray analysis can be used as an exploratory method to investigate how genes and gene clusters are modulated acutely and chronically by RE. The purpose of the present study was to investigate the effect of training status in the basal (rested) and pre- to 24h post-RE on the global transcriptome in vastus lateralis muscle biopsies of young men. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

40 Samples

Download data: IDAT, TXT

(Submitter supplied) High-intensity intermittent exercise training (HIIT) has been proposed as an effective approach for improving both anaerobic and aerobic capacities. However, the molecular response of muscles to HIIT remains unknown. We used microarray to examine the effects of HIIT on global gene expression in human skeletal muscle.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16686

22 Samples

Download data: CEL

(Submitter supplied) We examined global mRNA expression using cDNA microarrays in skeletal muscle of humans before, and 3h and 48h after a single bout of exhaustive endurance exercise (cycling). Keywords: Time course

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1679

Platform:

GPL3457

8 Samples

Download data: GPR

(Submitter supplied) 8,432 randomly chosen cDNAs from a 40k Research Genetics human cDNA library were amplified under standard conditions (GeneAmp PCR System 9700) with the help of a volumetric robot (Tecan/Genesis, RSP150 and Tomtec/Quadra 384). Amplified products were transferred to a 384-well plates, purified transferred to 384-well print plates (Genetix), dried and resuspended in print buffer (3xSSC, 1.5M Betaine). more...

Organism:

Homo sapiens

2 DataSets

3 Series

15 Samples

Download data

Expression profiling of vastus lateralis muscles 3 and 48 hours after a 75-minute bout of high-intensity cycling. Results identify transcriptional pathways activated in skeletal muscles recovering from endurance exercise.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 2 time sets

Platform:

GPL3457

Series:

GSE4247

8 Samples

Download data: GPR

(Submitter supplied) Time course of mRNA after 30 minutes of endurance exercise at simulated altitude of 4000 m in an untrained or six weeks trained state of six subjects.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1935

44 Samples

Download data