U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PDE4DIP phosphodiesterase 4D interacting protein [ Homo sapiens (human) ]

    Gene ID: 9659, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PDE4DIPprovided by HGNC
    Official Full Name
    phosphodiesterase 4D interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:15580
    See related
    Ensembl:ENSG00000178104 MIM:608117; AllianceGenome:HGNC:15580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MMGL; CMYA2
    Summary
    The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
    Expression
    Biased expression in heart (RPKM 86.3), brain (RPKM 18.4) and 10 other tissues See more
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    1q21.2
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (148808434..149033016)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (145475230..145700086)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (144851427..145075933, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:145116171-145116728 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:145115612-145116170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145111649-145112460 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:145108701-145108867 Neighboring gene nudix hydrolase 4B Neighboring gene SEC22 homolog B3, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:145085325-145085826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145075157-145075794 Neighboring gene NANOG hESC enhancer GRCh37_chr1:145058822-145059364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145047676-145048176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145039786-145040507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145039063-145039785 Neighboring gene NANOG hESC enhancer GRCh37_chr1:145028802-145029303 Neighboring gene RN7SK pseudogene 88 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145023082-145023696 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145022466-145023081 Neighboring gene uncharacterized LOC112268272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145015143-145015643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144994512-144995132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144993892-144994511 Neighboring gene NANOG hESC enhancer GRCh37_chr1:144976465-144977040 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:144966957-144967786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:144961997-144962606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:144937763-144938539 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:144936334-144936835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:144932913-144933661 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:144931414-144932162 and GRCh37_chr1:144932163-144932912 Neighboring gene RNA, U2 small nuclear 38, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:144891435-144892634 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:144867459-144868658 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:144850469-144850968 Neighboring gene profilin-1-like Neighboring gene NBPF member 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1288 Neighboring gene uncharacterized LOC101929790

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis. Pan R, et al. Cell Death Dis, 2023 Jun 24. PMID 37355626, Free PMC Article
    2. Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene. Potashkin JA, et al. Int J Mol Sci, 2020 May 27. PMID 32471155, Free PMC Article
    3. Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma. Shimada H, et al. Int J Oncol, 2007 Jan. PMID 17143517
    4. Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction. Abou Ziki MD, et al. Hum Mutat, 2021 Oct. PMID 34289528, Free PMC Article
    5. Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome. Peng H, et al. Mol Biol Cell, 2021 Sep 1. PMID 34260267, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis.
      Title: PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis.
    2. Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction.
      Title: Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction.
    3. Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome.
      Title: Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome.
    4. Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene.
      Title: Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene.
    5. analysis of the recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma
      Title: Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma.
    6. A specific isoform of myomegalin, termed "SMYLE," promotes microtubule assembly and function.
      Title: EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.
    7. PDE4DIP genetic variation was associated with increased risk for ischemic stroke.
      Title: Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.
    8. A role of the SANS-myomegalin complex in microtubule-dependent inner segment cargo transport towards the ciliary base of photoreceptor cells.
      Title: Direct interaction of the Usher syndrome 1G protein SANS and myomegalin in the retina.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. MMGL-antibody is significantly with a favorable prognosis. Consequently, MMGL-anatibodies may be a useful tumor marker to diagnose and establish a prognosis in patients with esophageal squamous cell carcinoma.
      Title: Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of novel germline polymorphisms governing capecitabine sensitivity.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC75440, DKFZp781J054

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Golgi organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myofibril ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    myomegalin
    Names
    cardiomyopathy-associated protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027693.2 RefSeqGene

      Range
      41253..229841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001002810.5 → NP_001002810.1  myomegalin isoform 4

      See identical proteins and their annotated locations for NP_001002810.1

      Status: REVIEWED

      Source sequence(s)
      AC239802
      Consensus CDS
      CCDS72893.1
      UniProtKB/TrEMBL
      Q8TBR0
      Related
      ENSP00000358353.4, ENST00000369347.8
      Conserved Domains (2) summary
      pfam07989
      Location:6 → 73
      Cnn_1N; Centrosomin N-terminal motif 1
      cl26527
      Location:39 → 135
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein

    2. NM_001002811.3 → NP_001002811.2  myomegalin isoform 5

      See identical proteins and their annotated locations for NP_001002811.2

      Status: REVIEWED

      Source sequence(s)
      AC239802
      Consensus CDS
      CCDS72894.1
      UniProtKB/Swiss-Prot
      Q5VU43
      Related
      ENSP00000316434.9, ENST00000313431.13
      Conserved Domains (2) summary
      pfam07776
      Location:4 → 74
      zf-AD; Zinc-finger associated domain (zf-AD)
      cl25732
      Location:403 → 1095
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_001002812.4 → NP_001002812.2  myomegalin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC239802
      Consensus CDS
      CCDS72890.1
      UniProtKB/Swiss-Prot
      Q5VU43
      UniProtKB/TrEMBL
      A0A0A0MRL8
      Related
      ENSP00000358355.3, ENST00000369349.7
      Conserved Domains (3) summary
      TIGR02168
      Location:30 → 679
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07851
      Location:242 → 337
      TMPIT; TMPIT-like protein
      pfam07989
      Location:6 → 73
      Cnn_1N; Centrosomin N-terminal motif 1

    4. NM_001195260.2 → NP_001182189.1  myomegalin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC239802, BC025406, BI550399, CB529851, DA766011
      UniProtKB/Swiss-Prot
      Q5VU43
      Conserved Domains (2) summary
      PRK12704
      Location:2 → 113
      PRK12704; phosphodiesterase; Provisional
      pfam07989
      Location:1 → 41
      Cnn_1N; Centrosomin N-terminal motif 1

    5. NM_001195261.2 → NP_001182190.1  myomegalin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC239802, BC025406, BG776644, CB529851, DA766011
      UniProtKB/TrEMBL
      E9PS60
      Related
      ENSP00000435920.1, ENST00000534536.5
      Conserved Domains (2) summary
      pfam07989
      Location:13 → 76
      Cnn_1N; Centrosomin N-terminal motif 1
      pfam16046
      Location:53 → 118
      FAM76; FAM76 protein

    6. NM_001198832.4 → NP_001185761.2  myomegalin isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      Consensus CDS
      CCDS72888.1
      UniProtKB/TrEMBL
      A0A087WX83
      Related
      ENSP00000479409.1, ENST00000618462.4
      Conserved Domains (8) summary
      COG1196
      Location:421 → 1206
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05456
      Location:2009 → 2056
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
      pfam06758
      Location:1519 → 1580
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07851
      Location:308 → 403
      TMPIT; TMPIT-like protein
      pfam07989
      Location:72 → 139
      Cnn_1N; Centrosomin N-terminal motif 1
      pfam15678
      Location:1823 → 1886
      SPICE; Centriole duplication and mitotic chromosome congression
      cl09111
      Location:116 → 233
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    7. NM_001198834.5 → NP_001185763.3  myomegalin isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804
      Consensus CDS
      CCDS72892.1
      UniProtKB/TrEMBL
      A0A087WX83
      Related
      ENSP00000358363.4, ENST00000369356.8
      Conserved Domains (7) summary
      TIGR02168
      Location:5 → 679
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05456
      Location:2115 → 2162
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
      pfam06758
      Location:1563 → 1624
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07851
      Location:242 → 337
      TMPIT; TMPIT-like protein
      pfam07989
      Location:6 → 73
      Cnn_1N; Centrosomin N-terminal motif 1
      pfam15678
      Location:1929 → 1992
      SPICE; Centriole duplication and mitotic chromosome congression
      cl09111
      Location:50 → 167
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    8. NM_001350520.2 → NP_001337449.1  myomegalin isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804
      Consensus CDS
      CCDS91044.1
      UniProtKB/TrEMBL
      A0A087WX83, A0A994J5E0
      Related
      ENSP00000516056.1, ENST00000704840.1
      Conserved Domains (3) summary
      pfam06758
      Location:1718 → 1785
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07776
      Location:4 → 74
      zf-AD; Zinc-finger associated domain (zf-AD)
      cl25732
      Location:403 → 1237
      SMC_N; RecF/RecN/SMC N terminal domain

    9. NM_001350521.4 → NP_001337450.1  myomegalin isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      pfam06758
      Location:1693 → 1760
      DUF1220; Repeat of unknown function (DUF1220)
      cl25732
      Location:140 → 816
      SMC_N; RecF/RecN/SMC N terminal domain

    10. NM_001350522.3 → NP_001337451.1  myomegalin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A9L9PY76
      Conserved Domains (2) summary
      pfam06758
      Location:1622 → 1689
      DUF1220; Repeat of unknown function (DUF1220)
      cl25732
      Location:69 → 745
      SMC_N; RecF/RecN/SMC N terminal domain

    11. NM_001350523.3 → NP_001337452.1  myomegalin isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      pfam06758
      Location:1511 → 1578
      DUF1220; Repeat of unknown function (DUF1220)
      cl25732
      Location:69 → 745
      SMC_N; RecF/RecN/SMC N terminal domain

    12. NM_001377392.2 → NP_001364321.1  myomegalin isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      Consensus CDS
      CCDS91040.1
      UniProtKB/TrEMBL
      A0A087WX83, A0A8Q3WM32
      Related
      ENSP00000512174.1, ENST00000695794.1
      Conserved Domains (5) summary
      COG0419
      Location:167 → 767
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1981 → 2203
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:377 → 1175
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06758
      Location:1693 → 1760
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07989
      Location:143 → 210
      Cnn_1N; Centrosomin N-terminal motif 1

    13. NM_001377393.2 → NP_001364322.1  myomegalin isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (5) summary
      COG0419
      Location:96 → 696
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1800 → 2022
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:306 → 1104
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06758
      Location:1512 → 1579
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07989
      Location:72 → 139
      Cnn_1N; Centrosomin N-terminal motif 1

    14. NM_001395297.1 → NP_001382226.1  myomegalin isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      COG1196
      Location:2007 → 2229
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:403 → 1237
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    15. NM_001395298.1 → NP_001382227.1  myomegalin isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      Consensus CDS
      CCDS91041.1
      UniProtKB/TrEMBL
      A0A075B749, A0A087WX83
      Related
      ENSP00000462316.2, ENST00000585156.5
      Conserved Domains (5) summary
      COG0419
      Location:167 → 767
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1980 → 2202
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:377 → 1175
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06758
      Location:1692 → 1759
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07989
      Location:143 → 210
      Cnn_1N; Centrosomin N-terminal motif 1

    16. NM_001395299.1 → NP_001382228.1  myomegalin isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      COG1196
      Location:1944 → 2166
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:403 → 1201
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    17. NM_001395300.1 → NP_001382229.1  myomegalin isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (3) summary
      COG0419
      Location:140 → 730
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:1944 → 2166
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:340 → 1138
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    18. NM_001395301.1 → NP_001382230.1  myomegalin isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      COG1196
      Location:2006 → 2175
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:403 → 1201
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    19. NM_001395302.1 → NP_001382231.1  myomegalin isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      Consensus CDS
      CCDS91042.1
      UniProtKB/TrEMBL
      A0A087WX83, A0A8Q3SI21
      Related
      ENSP00000512160.1, ENST00000695768.1
      Conserved Domains (3) summary
      COG1196
      Location:1944 → 2113
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:150 → 779
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:495 → 1231
      SMC_N; RecF/RecN/SMC N terminal domain

    20. NM_001395303.1 → NP_001382232.1  myomegalin isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      COG1196
      Location:1870 → 2092
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:140 → 816
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    21. NM_001395304.1 → NP_001382233.1  myomegalin isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      COG1196
      Location:1848 → 2017
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    22. NM_001395305.1 → NP_001382234.1  myomegalin isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      COG1196
      Location:1848 → 2017
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    23. NM_001395306.1 → NP_001382235.1  myomegalin isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      COG1196
      Location:1800 → 2022
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    24. NM_001395307.1 → NP_001382236.1  myomegalin isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      COG1196
      Location:1870 → 2055
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:140 → 816
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    25. NM_001395308.1 → NP_001382237.1  myomegalin isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A9L9PY76
      Conserved Domains (2) summary
      COG1196
      Location:1847 → 2032
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    26. NM_001395309.1 → NP_001382238.1  myomegalin isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804
      Conserved Domains (2) summary
      COG1196
      Location:1783 → 2005
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:403 → 1247
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    27. NM_001395310.1 → NP_001382239.1  myomegalin isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A9L9PY76
      Related
      ENSP00000516481.1, ENST00000706647.1
      Conserved Domains (2) summary
      COG1196
      Location:1848 → 2033
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    28. NM_001395311.1 → NP_001382240.1  myomegalin isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      COG1196
      Location:1738 → 1907
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    29. NM_001395312.1 → NP_001382241.1  myomegalin isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A087WX83
      Conserved Domains (2) summary
      COG1196
      Location:421 → 1336
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    30. NM_001395313.1 → NP_001382242.1  myomegalin isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A9L9PY76
      Conserved Domains (2) summary
      COG1196
      Location:1811 → 1996
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:79 → 708
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    31. NM_001395314.1 → NP_001382243.1  myomegalin isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      UniProtKB/TrEMBL
      A0A9L9PY76
      Conserved Domains (2) summary
      COG1196
      Location:421 → 1336
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    32. NM_001395315.1 → NP_001382244.1  myomegalin isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC239802
      Consensus CDS
      CCDS91045.1
      Related
      ENSP00000433392.1, ENST00000529945.2
      Conserved Domains (2) summary
      TIGR02168
      Location:453 → 1095
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18615
      Location:1 → 376
      SMYLE_N; Short myomegalin-like EB1 binding proteins, N-terminal domain

    33. NM_001395316.1 → NP_001382245.1  myomegalin isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      Conserved Domains (1) summary
      TIGR02168
      Location:140 → 816
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    34. NM_001395317.1 → NP_001382246.1  myomegalin isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      Conserved Domains (2) summary
      PRK02224
      Location:611 → 1088
      PRK02224; DNA double-strand break repair Rad50 ATPase
      TIGR02168
      Location:140 → 816
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    35. NM_001395318.1 → NP_001382247.1  myomegalin isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      Conserved Domains (1) summary
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    36. NM_001395319.1 → NP_001382248.1  myomegalin isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      Conserved Domains (1) summary
      TIGR02168
      Location:53 → 729
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    37. NM_001395320.1 → NP_001382249.1  myomegalin isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      Conserved Domains (1) summary
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    38. NM_001395321.1 → NP_001382250.1  myomegalin isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      Conserved Domains (1) summary
      TIGR02168
      Location:79 → 708
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    39. NM_001395322.1 → NP_001382251.1  myomegalin isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      Conserved Domains (1) summary
      TIGR02168
      Location:18 → 647
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    40. NM_001395323.1 → NP_001382252.1  myomegalin isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC239802
      Consensus CDS
      CCDS91046.1
      UniProtKB/TrEMBL
      E9PQG4
      Related
      ENSP00000436791.1, ENST00000479408.6
      Conserved Domains (2) summary
      TIGR02168
      Location:151 → 466
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:28 → 724
      SMC_N; RecF/RecN/SMC N terminal domain

    41. NM_001395324.1 → NP_001382253.1  myomegalin isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC239802
      Conserved Domains (2) summary
      TIGR02168
      Location:151 → 464
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:28 → 722
      SMC_N; RecF/RecN/SMC N terminal domain

    42. NM_001395325.1 → NP_001382254.1  myomegalin isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      UniProtKB/TrEMBL
      A0A8Q3SI11
      Related
      ENSP00000512159.1, ENST00000695767.1
      Conserved Domains (1) summary
      COG1196
      Location:140 → 342
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    43. NM_001395326.1 → NP_001382255.1  myomegalin isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      UniProtKB/TrEMBL
      A0A8Q3SI71
      Related
      ENSP00000512161.1, ENST00000695769.1
      Conserved Domains (1) summary
      COG1196
      Location:67 → 271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    44. NM_001395327.1 → NP_001382256.1  myomegalin isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      UniProtKB/TrEMBL
      A0A8Q3SI71
      Conserved Domains (1) summary
      COG4942
      Location:57 → 234
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

    45. NM_001395328.1 → NP_001382257.1  myomegalin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389

    46. NM_001395329.1 → NP_001382258.1  myomegalin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      Conserved Domains (2) summary
      PRK12704
      Location:2 → 113
      PRK12704; phosphodiesterase; Provisional
      pfam07989
      Location:1 → 41
      Cnn_1N; Centrosomin N-terminal motif 1

    47. NM_001395426.1 → NP_001382355.1  myomegalin isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804, AC245389
      Consensus CDS
      CCDS91043.1
      UniProtKB/TrEMBL
      A0A087WX83, A0A8Q3SI83
      Related
      ENSP00000512175.1, ENST00000695795.1
      Conserved Domains (2) summary
      COG1196
      Location:1910 → 2132
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:69 → 745
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    48. NM_014644.7 → NP_055459.5  myomegalin isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC239804
      Consensus CDS
      CCDS72891.1
      UniProtKB/Swiss-Prot
      A0A0A0MRM0, A0A0C4DFQ0, A2RU15, E9PL24, O75042, O75065, Q2YDC1, Q5VU42, Q5VU43, Q5VU44, Q5VU45, Q5VU46, Q5VU47, Q5VU48, Q5VU49, Q68DU2, Q6AZ93, Q6PK88, Q86T40, Q86TB2, Q8N3W0, Q8TAY9, Q9HCP2, Q9HCP3, Q9HCP4, Q9HCP5
      UniProtKB/TrEMBL
      A0A087WX83
      Related
      ENSP00000358360.3, ENST00000369354.7
      Conserved Domains (2) summary
      pfam06758
      Location:1556 → 1623
      DUF1220; Repeat of unknown function (DUF1220)
      cl25732
      Location:5 → 679
      SMC_N; RecF/RecN/SMC N terminal domain

    49. NM_022359.8 → NP_071754.3  myomegalin isoform 3

      See identical proteins and their annotated locations for NP_071754.3

      Status: REVIEWED

      Source sequence(s)
      AC239802, AC245389
      Consensus CDS
      CCDS72887.1
      UniProtKB/TrEMBL
      A0A8Q3SI11
      Related
      ENSP00000482121.1, ENST00000530472.5
      Conserved Domains (2) summary
      pfam07989
      Location:143 → 210
      Cnn_1N; Centrosomin N-terminal motif 1
      cl09111
      Location:187 → 304
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      148808434..149033016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      145475230..145700086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VU43.3 GenPept UniProtKB/Swiss-Prot:Q5VU43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous