Plec plectin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plecprovided by RGD
Official Full Name: plectinprovided by RGD
Primary source: RGD:621649
See related: Ensembl:ENSRNOG00000023781 AllianceGenome:RGD:621649
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pcn; Pltn; Plec1
Summary: Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (for reviews see PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were replaced by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (human variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]
Expression: Biased expression in Muscle (RPKM 513.4), Heart (RPKM 233.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (109768447..109829798, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (107887764..107949100, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (117230319..117291859, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings indicated that plectin protects podocytes from ADR-induced apoptosis and F-actin cytoskeletal disruption by inhibiting integrin alpha6beta4/FAK/p38 pathway activation and that plectin may be a therapeutic target for podocyte injury-related glomerular diseases.
Title: Plectin protects podocytes from adriamycin-induced apoptosis and F-actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway.
Localization of plectin, cytoskeletal linker protein, showed decrease in all the stages of spermatogenesis following estradiol treatment.
Title: Altered phosphorylation and distribution status of vimentin in rat seminiferous epithelium following 17β-estradiol treatment.
the DG-plectin complex plays a central role in transmitting mechanical stress from the extracellular matrix to the cytoplasm.
Title: A dystroglycan/plectin scaffold mediates mechanical pathway bifurcation in lung epithelial cells.
plectin is expressed in rat SCG neurons as a rodless isoform with the molecular mass of 390 kDa
Title: Identification of the cytolinker protein plectin in neuronal cells - expression of a rodless isoform in neurons of the rat superior cervical ganglion.
propose that the caspase 8-mediated degradation of plectin represents a critical biochemical event during CCK-induced secretory blockade and pancreatic acinar cell injury
Title: Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis.
naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes
Title: Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes.
plectin binds to Fer kinase
Title: Direct binding of plectin to Fer kinase and negative regulation of its catalytic activity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131032 (e-PCR)
- UniSTS:214315

RH129479 (e-PCR)
- UniSTS:212785

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables ankyrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ankyrin binding	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IDA Inferred from Direct Assay more info	PubMed
enables dystroglycan binding	IEA Inferred from Electronic Annotation more info
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actomyosin contractile ring assembly actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in actomyosin contractile ring assembly actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info
involved_in adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fluid shear stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrostatic pressure	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrostatic pressure	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of skin barrier	IEA Inferred from Electronic Annotation more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in hemidesmosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in hemidesmosome assembly	IEA Inferred from Electronic Annotation more info
involved_in hemidesmosome assembly	ISO Inferred from Sequence Orthology more info
involved_in hemidesmosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in intermediate filament cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IEA Inferred from Electronic Annotation more info
involved_in intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte development	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte development	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in nucleus organization	IEA Inferred from Electronic Annotation more info
involved_in nucleus organization	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system myelin maintenance	IEA Inferred from Electronic Annotation more info
involved_in peripheral nervous system myelin maintenance	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IEA Inferred from Electronic Annotation more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex organization	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in respiratory electron transport chain	ISO Inferred from Sequence Orthology more info
involved_in response to food	IEA Inferred from Electronic Annotation more info
involved_in response to food	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in sarcomere organization	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in skeletal myofibril assembly	IEA Inferred from Electronic Annotation more info
involved_in skeletal myofibril assembly	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in tight junction organization	IEA Inferred from Electronic Annotation more info
involved_in tight junction organization	ISO Inferred from Sequence Orthology more info
involved_in transmission of nerve impulse	IEA Inferred from Electronic Annotation more info
involved_in transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
is_active_in Z disc	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in axon	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
is_active_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in contractile muscle fiber	ISO Inferred from Sequence Orthology more info
located_in costamere	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in hemidesmosome	IBA Inferred from Biological aspect of Ancestor more info
located_in hemidesmosome	IEA Inferred from Electronic Annotation more info
is_active_in hemidesmosome	ISO Inferred from Sequence Orthology more info
located_in hemidesmosome	ISO Inferred from Sequence Orthology more info
located_in hemidesmosome	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	IEA Inferred from Electronic Annotation more info
is_active_in myelin sheath	ISO Inferred from Sequence Orthology more info
is_active_in myofibril	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
is_active_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: plectin

Names: plectin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164296.3 → NP_001157768.1 plectin isoform 1c

See identical proteins and their annotated locations for NP_001157768.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) contains the 5'-most coding exon (exon 1c) and encodes isoform 1c.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6HS66, F1MAL6, Q6S3A5

Conserved Domains (10) summary

smart00250
Location:3120 → 3156

PLEC; Plectin repeat

cd00014
Location:72 → 174

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:644 → 822

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:189 → 287

CH; Calponin homology (CH) domain

pfam00681
Location:3489 → 3530

Plectin; Plectin repeat

pfam01576
Location:1407 → 2553

Myosin_tail_1; Myosin tail

cd16269
Location:2358 → 2371

GBP_C; coiled coil [structural motif]

cl02488
Location:1752 → 1927

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:2207 → 2391

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1497 → 1588

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001164297.3 → NP_001157769.1 plectin isoform 1f

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as 1f, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1f) contains a distinct N-terminus compared to isoform 1c.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

Q6S3A4

Related

ENSRNOP00000070533.2, ENSRNOT00000091285.2

Conserved Domains (10) summary

smart00250
Location:3082 → 3118

PLEC; Plectin repeat

cd00014
Location:34 → 136

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:606 → 784

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:151 → 249

CH; Calponin homology (CH) domain

pfam00681
Location:3451 → 3492

Plectin; Plectin repeat

pfam01576
Location:1369 → 2515

Myosin_tail_1; Myosin tail

cd16269
Location:2320 → 2333

GBP_C; coiled coil [structural motif]

cl02488
Location:1714 → 1889

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:2169 → 2353

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1459 → 1550

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001164298.3 → NP_001157770.1 plectin isoform 1e

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as 1e, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1e) contains a distinct N-terminus compared to isoform 1c.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

Q6S3A3

Conserved Domains (9) summary

smart00250
Location:3069 → 3105

PLEC; Plectin repeat

cd00014
Location:21 → 123

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:593 → 771

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:138 → 236

CH; Calponin homology (CH) domain

pfam00681
Location:3438 → 3479

Plectin; Plectin repeat

pfam01576
Location:1356 → 2502

Myosin_tail_1; Myosin tail

cd16269
Location:2307 → 2320

GBP_C; coiled coil [structural motif]

cl20817
Location:2156 → 2340

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1446 → 1537

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001164299.3 → NP_001157771.1 plectin isoform 1hij

See identical proteins and their annotated locations for NP_001157771.1

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as 1i, contains an alternate 5' terminal exon which results in a distinct 5' UTR and causes translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5 and 9 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

Q6S3A1

Conserved Domains (8) summary

smart00250
Location:2934 → 2970

PLEC; Plectin repeat

cd00176
Location:458 → 636

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:3 → 101

CH; Calponin homology (CH) domain

pfam00681
Location:3303 → 3344

Plectin; Plectin repeat

pfam01576
Location:1221 → 2367

Myosin_tail_1; Myosin tail

cd16269
Location:2172 → 2185

GBP_C; coiled coil [structural motif]

cl20817
Location:2088 → 2205

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1311 → 1402

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001164302.3 → NP_001157774.1 plectin isoform 1hij

See identical proteins and their annotated locations for NP_001157774.1

Status: REVIEWED

Description

Transcript Variant: This variant (5), also known as 1j, contains an alternate 5' terminal exon which results in a distinct 5' UTR and causes translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5 and 9 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

Q6S3A1

Conserved Domains (8) summary

smart00250
Location:2934 → 2970

PLEC; Plectin repeat

cd00176
Location:458 → 636

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:3 → 101

CH; Calponin homology (CH) domain

pfam00681
Location:3303 → 3344

Plectin; Plectin repeat

pfam01576
Location:1221 → 2367

Myosin_tail_1; Myosin tail

cd16269
Location:2172 → 2185

GBP_C; coiled coil [structural motif]

cl20817
Location:2088 → 2205

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1311 → 1402

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001164303.3 → NP_001157775.1 plectin isoform 1d

Status: REVIEWED

Description

Transcript Variant: This variant (7), also known as 1d, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1d) contains a distinct N-terminus compared to isoform 1c.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

Q6S399

Related

ENSRNOP00000070850.2, ENSRNOT00000086550.2

Conserved Domains (10) summary

smart00250
Location:3059 → 3095

PLEC; Plectin repeat

cd00014
Location:11 → 113

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:583 → 761

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:128 → 226

CH; Calponin homology (CH) domain

pfam00681
Location:3428 → 3469

Plectin; Plectin repeat

pfam01576
Location:1346 → 2492

Myosin_tail_1; Myosin tail

cd16269
Location:2297 → 2310

GBP_C; coiled coil [structural motif]

cl02488
Location:1691 → 1866

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:2146 → 2330

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1436 → 1527

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001164304.3 → NP_001157776.1 plectin isoform 1b

Status: REVIEWED

Description

Transcript Variant: This variant (8), also known as 1b, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1b) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1b has been found to associate exclusively with mitochondria (PMID: 18541706, 14559777).

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

Q6S398

Conserved Domains (10) summary

smart00250
Location:3091 → 3127

PLEC; Plectin repeat

cd00014
Location:43 → 145

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:615 → 793

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:160 → 258

CH; Calponin homology (CH) domain

pfam00681
Location:3460 → 3501

Plectin; Plectin repeat

pfam01576
Location:1378 → 2524

Myosin_tail_1; Myosin tail

cd16269
Location:2329 → 2342

GBP_C; coiled coil [structural motif]

cl02488
Location:1723 → 1898

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:2178 → 2362

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1468 → 1559

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001164305.3 → NP_001157777.1 plectin isoform 1hij

See identical proteins and their annotated locations for NP_001157777.1

Status: REVIEWED

Description

Transcript Variant: This variant (9), also known as 1h, contains an alternate 5' terminal exon which results in a distinct 5' UTR and causes translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5 and 9 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

Q6S3A1

Conserved Domains (8) summary

smart00250
Location:2934 → 2970

PLEC; Plectin repeat

cd00176
Location:458 → 636

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:3 → 101

CH; Calponin homology (CH) domain

pfam00681
Location:3303 → 3344

Plectin; Plectin repeat

pfam01576
Location:1221 → 2367

Myosin_tail_1; Myosin tail

cd16269
Location:2172 → 2185

GBP_C; coiled coil [structural motif]

cl20817
Location:2088 → 2205

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1311 → 1402

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001164307.3 → NP_001157779.1 plectin isoform 1g

Status: REVIEWED

Description

Transcript Variant: This variant (10), also known as 1g, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1g) contains a distinct N-terminus compared to isoform 1c.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

Q6S396

Conserved Domains (10) summary

smart00250
Location:3098 → 3134

PLEC; Plectin repeat

cd00014
Location:50 → 152

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:622 → 800

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:167 → 265

CH; Calponin homology (CH) domain

pfam00681
Location:3467 → 3508

Plectin; Plectin repeat

pfam01576
Location:1385 → 2531

Myosin_tail_1; Myosin tail

cd16269
Location:2336 → 2349

GBP_C; coiled coil [structural motif]

cl02488
Location:1730 → 1905

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:2185 → 2369

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1475 → 1566

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001164308.3 → NP_001157780.1 plectin isoform 1a

Status: REVIEWED

Description

Transcript Variant: This variant (11), also known as 1a, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1a) contains a distinct N-terminus compared to isoform 1c.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

F7F744, Q6S395

Conserved Domains (10) summary

smart00250
Location:3091 → 3127

PLEC; Plectin repeat

cd00014
Location:43 → 145

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:615 → 793

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:160 → 258

CH; Calponin homology (CH) domain

pfam00681
Location:3460 → 3501

Plectin; Plectin repeat

pfam01576
Location:1378 → 2524

Myosin_tail_1; Myosin tail

cd16269
Location:2329 → 2342

GBP_C; coiled coil [structural motif]

cl02488
Location:1723 → 1898

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:2178 → 2362

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1468 → 1559

ATP-synt_B; ATP synthase B/B' CF(0)
NM_022401.4 → NP_071796.2 plectin isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1) contains a distinct N-terminus compared to isoform 1c.

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6HS68, Q6S3A0

Conserved Domains (11) summary

smart00250
Location:3234 → 3270

PLEC; Plectin repeat

cd00014
Location:186 → 288

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:758 → 936

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:303 → 401

CH; Calponin homology (CH) domain

pfam00681
Location:3603 → 3644

Plectin; Plectin repeat

pfam01576
Location:1521 → 2667

Myosin_tail_1; Myosin tail

pfam03501
Location:7 → 101

S10_plectin; Plectin/S10 domain

cd16269
Location:2472 → 2485

GBP_C; coiled coil [structural motif]

cl02488
Location:1866 → 2041

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:2321 → 2505

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1611 → 1702

ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

109768447..109829798 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264209.1 → XP_063120279.1 plectin isoform X8

UniProtKB/TrEMBL

A6HS66, F1MAL6, Q6S3A5
XM_017595088.3 → XP_017450577.1 plectin isoform X6

UniProtKB/TrEMBL

A6HS67
XM_063264210.1 → XP_063120280.1 plectin isoform X8

UniProtKB/TrEMBL

A6HS66, F1MAL6, Q6S3A5
XM_017595087.3 → XP_017450576.1 plectin isoform X6

UniProtKB/TrEMBL

A6HS67
XM_063264208.1 → XP_063120278.1 plectin isoform X6

UniProtKB/TrEMBL

A6HS67
XM_017595089.3 → XP_017450578.1 plectin isoform X7

UniProtKB/TrEMBL

A6HS67
XM_017595086.3 → XP_017450575.1 plectin isoform X6

UniProtKB/TrEMBL

A6HS67
XM_063264212.1 → XP_063120282.1 plectin isoform X22
XM_006241875.5 → XP_006241937.1 plectin isoform X8

See identical proteins and their annotated locations for XP_006241937.1

UniProtKB/TrEMBL

A6HS66, F1MAL6, Q6S3A5

Conserved Domains (10) summary

smart00250
Location:3120 → 3156

PLEC; Plectin repeat

cd00014
Location:72 → 174

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:644 → 822

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:189 → 287

CH; Calponin homology (CH) domain

pfam00681
Location:3489 → 3530

Plectin; Plectin repeat

pfam01576
Location:1407 → 2553

Myosin_tail_1; Myosin tail

cd16269
Location:2358 → 2371

GBP_C; coiled coil [structural motif]

cl02488
Location:1752 → 1927

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:2207 → 2391

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1497 → 1588

ATP-synt_B; ATP synthase B/B' CF(0)
XM_017595097.3 → XP_017450586.1 plectin isoform X17

UniProtKB/TrEMBL

Q6S3A4
XM_017595096.3 → XP_017450585.1 plectin isoform X15

UniProtKB/TrEMBL

A0A0G2JY63
XM_017595085.3 → XP_017450574.2 plectin isoform X5

UniProtKB/TrEMBL

Q6S3A3

Conserved Domains (9) summary

PTZ00121
Location:1332 → 2038

PTZ00121; MAEBL; Provisional

smart00250
Location:3081 → 3117

PLEC; Plectin repeat

COG0419
Location:1013 → 1549

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd00176
Location:605 → 783

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00681
Location:4028 → 4067

Plectin; Plectin repeat

pfam17902
Location:780 → 846

SH3_10; SH3 domain

pfam18373
Location:881 → 958

Spectrin_like; Spectrin like domain

cd21188
Location:19 → 135

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21238
Location:148 → 253

CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins
XM_017595084.3 → XP_017450573.2 plectin isoform X4

UniProtKB/TrEMBL

Q6S3A3

Conserved Domains (9) summary

PTZ00121
Location:1337 → 2043

PTZ00121; MAEBL; Provisional

smart00250
Location:3086 → 3122

PLEC; Plectin repeat

COG0419
Location:1018 → 1554

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd00176
Location:610 → 788

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00681
Location:4033 → 4072

Plectin; Plectin repeat

pfam17902
Location:785 → 851

SH3_10; SH3 domain

pfam18373
Location:886 → 963

Spectrin_like; Spectrin like domain

cd21188
Location:19 → 140

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21238
Location:153 → 258

CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins
XM_017595083.3 → XP_017450572.1 plectin isoform X2

UniProtKB/TrEMBL

A6HS68, Q6S3A0
XM_017595082.3 → XP_017450571.1 plectin isoform X1

UniProtKB/TrEMBL

A6HS68, Q6S3A0
XM_006241870.5 → XP_006241932.1 plectin isoform X3

UniProtKB/TrEMBL

A0A0G2K5T2, A6HS68, Q6S3A0

Related

ENSRNOP00000073548.2

Conserved Domains (11) summary

smart00250
Location:3239 → 3275

PLEC; Plectin repeat

cd00014
Location:186 → 293

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:763 → 941

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:308 → 406

CH; Calponin homology (CH) domain

pfam00681
Location:3608 → 3649

Plectin; Plectin repeat

pfam01576
Location:1526 → 2672

Myosin_tail_1; Myosin tail

pfam03501
Location:7 → 101

S10_plectin; Plectin/S10 domain

cd16269
Location:2477 → 2490

GBP_C; coiled coil [structural motif]

cl02488
Location:1871 → 2046

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:2326 → 2510

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1616 → 1707

ATP-synt_B; ATP synthase B/B' CF(0)
XM_039079851.2 → XP_038935779.1 plectin isoform X21

Conserved Domains (10) summary

smart00250
Location:2956 → 2993

PLEC; Plectin repeat

COG0419
Location:1183 → 1565

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd00176
Location:775 → 953

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02169
Location:590 → 931

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam00681
Location:3071 → 3110

Plectin; Plectin repeat

pfam03501
Location:7 → 99

S10_plectin; Plectin/S10 domain

pfam17902
Location:950 → 1016

SH3_10; SH3 domain

pfam18373
Location:1051 → 1128

Spectrin_like; Spectrin like domain

cd21188
Location:184 → 305

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21238
Location:318 → 423

CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins
XM_039079850.2 → XP_038935778.1 plectin isoform X19

UniProtKB/TrEMBL

Q6S399

Conserved Domains (9) summary

PTZ00121
Location:1322 → 2028

PTZ00121; MAEBL; Provisional

smart00250
Location:3071 → 3107

PLEC; Plectin repeat

COG0419
Location:1003 → 1539

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd00176
Location:595 → 773

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00681
Location:4018 → 4057

Plectin; Plectin repeat

pfam17902
Location:770 → 836

SH3_10; SH3 domain

pfam18373
Location:871 → 948

Spectrin_like; Spectrin like domain

cd21188
Location:9 → 125

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21238
Location:138 → 243

CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins
XM_039079848.2 → XP_038935776.1 plectin isoform X18

UniProtKB/TrEMBL

A0A0G2JYZ5

Conserved Domains (9) summary

PTZ00121
Location:1327 → 2033

PTZ00121; MAEBL; Provisional

smart00250
Location:3076 → 3112

PLEC; Plectin repeat

COG0419
Location:1008 → 1544

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd00176
Location:600 → 778

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00681
Location:4023 → 4062

Plectin; Plectin repeat

pfam17902
Location:775 → 841

SH3_10; SH3 domain

pfam18373
Location:876 → 953

Spectrin_like; Spectrin like domain

cd21188
Location:9 → 130

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21238
Location:143 → 248

CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins
XM_017595095.3 → XP_017450584.1 plectin isoform X14

UniProtKB/TrEMBL

Q6S398
XM_006241882.4 → XP_006241944.1 plectin isoform X16

UniProtKB/TrEMBL

F7F9U6, Q6S398

Related

ENSRNOP00000044096.5

Conserved Domains (10) summary

smart00250
Location:3096 → 3132

PLEC; Plectin repeat

cd00014
Location:43 → 150

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:620 → 798

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:165 → 263

CH; Calponin homology (CH) domain

pfam00681
Location:3465 → 3506

Plectin; Plectin repeat

pfam01576
Location:1383 → 2529

Myosin_tail_1; Myosin tail

cd16269
Location:2334 → 2347

GBP_C; coiled coil [structural motif]

cl02488
Location:1728 → 1903

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:2183 → 2367

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1473 → 1564

ATP-synt_B; ATP synthase B/B' CF(0)
XM_017595093.3 → XP_017450582.1 plectin isoform X12

UniProtKB/TrEMBL

Q6S398
XM_017595090.3 → XP_017450579.1 plectin isoform X9

UniProtKB/TrEMBL

Q6S396
XM_017595091.3 → XP_017450580.1 plectin isoform X10

UniProtKB/TrEMBL

Q6S396
XM_063264211.1 → XP_063120281.1 plectin isoform X20

UniProtKB/TrEMBL

Q6S3A1
XM_017595094.3 → XP_017450583.1 plectin isoform X13

UniProtKB/TrEMBL

F7F744, Q6S395
XM_017595092.3 → XP_017450581.1 plectin isoform X11

UniProtKB/TrEMBL

F7F744, Q6S395