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    F12 coagulation factor XII [ Canis lupus familiaris (dog) ]

    Gene ID: 489090, updated on 5-Mar-2024

    Summary

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    Gene symbol
    F12
    Gene description
    coagulation factor XII
    See related
    Ensembl:ENSCAFG00845010344
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (36316872..36334363)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (35918068..35935563)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (36837547..36855039)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (36142096..36159589)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (36328310..36345800)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene proline rich 7, synaptic Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene uncharacterized LOC111095525 Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3 Neighboring gene regulator of G protein signaling 14 Neighboring gene lectin, mannose binding 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in zymogen activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coagulation factor XII
    XP_038329496.1
    XP_038390569.1
    XP_038454873.1
    XP_038519176.1
    XP_546206.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      36316872..36334363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038663248.1 → XP_038519176.1  coagulation factor XII

      UniProtKB/TrEMBL
      A0A8C0SPV7, A0A8I3NR05
      Related
      ENSCAFP00845014210.1, ENSCAFT00845018220.1
      Conserved Domains (6) summary
      smart00059
      Location:41 → 88
      FN2; Fibronectin type 2 domain
      cd00054
      Location:96 → 131
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00061
      Location:133 → 171
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00190
      Location:365 → 608
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00008
      Location:178 → 208
      EGF; EGF-like domain
      cl00100
      Location:217 → 295
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

    RNA

    1. XR_005425735.1 RNA Sequence

    2. XR_005425734.1 RNA Sequence

    3. XR_005425736.1 RNA Sequence

    4. XR_005425737.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      36142096..36159589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038473568.1 → XP_038329496.1  coagulation factor XII

      Conserved Domains (6) summary
      smart00059
      Location:41 → 88
      FN2; Fibronectin type 2 domain
      cd00054
      Location:96 → 131
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00061
      Location:133 → 171
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00190
      Location:365 → 608
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00008
      Location:178 → 208
      EGF; EGF-like domain
      cl00100
      Location:217 → 295
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

    RNA

    1. XR_005324335.1 RNA Sequence

    2. XR_005324334.1 RNA Sequence

    3. XR_005324336.1 RNA Sequence

    4. XR_005324337.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      36328310..36345800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038598945.1 → XP_038454873.1  coagulation factor XII

    RNA

    1. XR_005392621.1 RNA Sequence

    2. XR_005392620.1 RNA Sequence

    3. XR_005392622.1 RNA Sequence

    4. XR_005392623.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      36837547..36855039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038534641.1 → XP_038390569.1  coagulation factor XII

      UniProtKB/TrEMBL
      A0A8C0SPV7, A0A8I3NR05
      Conserved Domains (6) summary
      smart00059
      Location:41 → 88
      FN2; Fibronectin type 2 domain
      cd00054
      Location:96 → 131
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00061
      Location:133 → 171
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00190
      Location:365 → 608
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00008
      Location:178 → 208
      EGF; EGF-like domain
      cl00100
      Location:217 → 295
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

    RNA

    1. XR_005358111.1 RNA Sequence

    2. XR_005358110.1 RNA Sequence

    3. XR_005358112.1 RNA Sequence

    4. XR_005358113.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      35918068..35935563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_546206.5 → XP_546206.3  coagulation factor XII

      UniProtKB/TrEMBL
      A0A8C0SPV7, A0A8P0SKJ6
      Conserved Domains (6) summary
      smart00059
      Location:41 → 88
      FN2; Fibronectin type 2 domain
      cd00054
      Location:96 → 131
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00061
      Location:133 → 171
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00190
      Location:365 → 608
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00008
      Location:178 → 208
      EGF; EGF-like domain
      cl00100
      Location:217 → 295
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

    RNA

    1. XR_005335287.1 RNA Sequence

    2. XR_005335285.1 RNA Sequence

    3. XR_005335288.1 RNA Sequence

    4. XR_005335290.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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