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    Zfp236 zinc finger protein 236 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291409, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp236provided by RGD
    Official Full Name
    zinc finger protein 236provided by RGD
    Primary source
    RGD:1309670
    See related
    Ensembl:ENSRNOG00000016303 AllianceGenome:RGD:1309670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to glucose stimulus and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF236 (zinc finger protein 236). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 96.1), Spleen (RPKM 68.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18q12.3
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (78251248..78351037, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (75976478..76072428, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (79447384..79543271, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene galanin receptor 1 Neighboring gene myelin basic protein Neighboring gene uncharacterized LOC108348833 Neighboring gene uncharacterized LOC120098255 Neighboring gene ribosomal protein L9, pseudogene 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of glucose-regulated genes in human mesangial cells by mRNA differential display. Holmes DI, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299475
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 236

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427206.1 → NP_001414135.1  zinc finger protein 236

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6AC96

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      78251248..78351037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255013.4 → XP_006255075.1  zinc finger protein 236 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A431
      Conserved Domains (5) summary
      COG5048
      Location:197 → 550
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1257 → 1277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:199 → 221
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1185 → 1209
      zf-H2C2_2; Zinc-finger double domain

    2. XM_008772218.4 → XP_008770440.1  zinc finger protein 236 isoform X1

      See identical proteins and their annotated locations for XP_008770440.1

      UniProtKB/TrEMBL
      A0A8I5ZXK0, A0A8I6A431
      Related
      ENSRNOP00000084581.1
      Conserved Domains (6) summary
      COG5048
      Location:181 → 534
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:185 → 205
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1241 → 1261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:183 → 205
      zf-C2H2; Zinc finger, C2H2 type
      pfam04005
      Location:1347 → 1581
      Hus1; Hus1-like protein
      pfam13465
      Location:1169 → 1193
      zf-H2C2_2; Zinc-finger double domain

    3. XM_063277157.1 → XP_063133227.1  zinc finger protein 236 isoform X2

    4. XM_039097350.2 → XP_038953278.1  zinc finger protein 236 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A431, F1LXC0
      Related
      ENSRNOP00000022086.8
      Conserved Domains (6) summary
      COG5048
      Location:78 → 431
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:82 → 102
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1138 → 1158
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1256 → 1451
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1066 → 1090
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:1544 → 1592
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    5. XM_039097349.2 → XP_038953277.1  zinc finger protein 236 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZJ55, A0A8I6A431
      Related
      ENSRNOP00000076412.1
      Conserved Domains (6) summary
      COG5048
      Location:97 → 450
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:101 → 121
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1157 → 1177
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:1275 → 1470
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13465
      Location:1085 → 1109
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:1563 → 1611
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    6. XM_039097351.2 → XP_038953279.1  zinc finger protein 236 isoform X7

      Conserved Domains (7) summary
      COG5048
      Location:213 → 618
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:732 → 752
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:934 → 1129
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00096
      Location:43 → 65
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:744 → 768
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:1222 → 1270
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    7. XM_006255016.5 → XP_006255078.1  zinc finger protein 236 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A431
      Conserved Domains (5) summary
      COG5048
      Location:197 → 550
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:201 → 221
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1257 → 1277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:199 → 221
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1185 → 1209
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_361554.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191696.1: Suppressed sequence

      Description
      NM_001191696.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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