Similar studies for GEO DataSets (Select 2197) - GEO DataSets

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Items: 17

Select item 21971.

Trans-10, cis-12 conjugated linoleic acid delipidiative effect on white adipose tissues: time course

Analysis of retroperitoneal white adipose tissue (WAT) of C57BL/6J males fed a diet containing 0.5% trans-10 ,cis-12 conjugated linoleic acid (t10c12 CLA) for up to 17 days. Results provide insight into the mechanisms underlying the reduction in fat content of mice WAT in response to t10c12 CLA.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 7 time sets

Platform:: GPL1261
Series:: GSE4671
28 Samples

Download data

DataSet

Accession:: GDS2197

ID:: 2197

Select item 2000046712.

Microarray Analysis of the Delipidation of White Adipose Tissue of Mice Fed Conjugated Linoleic Acid

(Submitter supplied) The white adipose tissue (WAT) rapidly loses mass when mice are fed a diet containing trans-10, cis-12 conjugated linoleic acid (t10c12 CLA). A microarray analysis of WAT due to CLA feeding was performed to better define the processes and genes involved. WAT weight decreased by ca. 80% over 17 days of feeding a 0.5% t10c12 CLA diet. The lipid volume decreased by 90% and the number of adipocytes and total cells were reduced by15% and 47%, respectively. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2197
Platform:: GPL1261
28 Samples

Download data

Series

Accession:: GSE4671

ID:: 200004671

Select item 2000015803.

Analysis of murine epididymal adipose tissue

(Submitter supplied) Functional genomic analysis of epididymal adipose tissue extracted from polygenic obese mice fed either a control (1% linoleic acid) or treatment (1% trans 10, cis 12 conjugated linoleic acid) diet after five or fourteen days. Keywords = Obesity Keywords = conjugated linoleic acid Keywords = polygenic obese mice Keywords = adiposity Keywords = lipid metabolism Keywords = apoptosis Keywords: repeat sample

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS1359 GDS1360
Platform:: GPL891
8 Samples

Download data: TIFF

Series

Accession:: GSE1580

ID:: 200001580

Select item 13604.

Conjugated linoleic acid delipidative effect on obese line: time course

Analysis of epididymal adipose tissue from M16 polygenic obese animals fed diet containing 1% trans-10 cis-12-conjugated linoleic acid (CLA). Body weight was 12% lower by day 14 on CLA diet. Adipose examined at 5 and 14 days. Results provide insight to mechanisms underlying CLA delipidative effect.

Organism:: Mus musculus

Type:: Expression profiling by array, log10 ratio, 2 time sets

Platform:: GPL891
Series:: GSE1580
4 Samples

Download data: TIFF

DataSet

Accession:: GDS1360

ID:: 1360

Select item 13595.

Conjugated linoleic acid delipidative effect on obese line: time course (dye-swap)

Organism:: Mus musculus

Type:: Expression profiling by array, log10 ratio, 2 time sets

Platform:: GPL891
Series:: GSE1580
4 Samples

Download data: TIFF

DataSet

Accession:: GDS1359

ID:: 1359

Select item 2000113846.

Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
66 Samples

Download data: CEL

Series

Accession:: GSE11384

ID:: 200011384

Select item 2000086847.

Gene expression in mouse 3T3-L1 adipocyte tissue culture treated with cis-9,trans-11 conjugated linoleic acid(c9t11 CLA)

(Submitter supplied) Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse 3T3-L1 adipocyte tissue culture; however cis-9, trans-11 CLA does not (this series). The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to c9t11 CLA. Their gene expression responses between 8 to 12 hr after treatment showed no gene expression changes indicative of an integrated stress response (ISR). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
10 Samples

Download data: CEL, XLS

Series

Accession:: GSE8684

ID:: 200008684

Select item 2000086838.

Gene expression in 3T3-L1 mouse tissue (preadipocytes) treated with Trans-10,Cis-12 conjugated linoleic acid(t10c12 CLA)

(Submitter supplied) Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse white adipose tissue (WAT) and 3T3-L1 adipocyte tissue culture; however in preadipocyte tissue (this series) the UPS/ISR and fat loss is not detected. The early transcriptome changes in 3T3-L1 preadipocyte tissue culture were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
11 Samples

Download data: CEL, XLS

Series

Accession:: GSE8683

ID:: 200008683

Select item 2000086829.

Gene expression in mouse 3T3-L1 adipocyte tissue culture treated with tunicamycin

(Submitter supplied) Tunycamcin induces UPR/ISR and Inflammation in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to tunicamycin, to be compared with similar experiments with CLA as the treatment. Their gene expression responses between 4 to 12 hr after treatment showed a common set of early gene expression changes indicative of a UPR/Inflammation stress response. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
8 Samples

Download data: CEL, XLS

Series

Accession:: GSE8682

ID:: 200008682

Select item 20000868110.

Gene expression in mouse 3T3-L1 adipocyte tissue culture treated with CLA

(Submitter supplied) Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Their gene expression responses between 4 to 24 hr after treatment showed a common set of early gene expression changes indicative of an integrated stress response (ISR). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
25 Samples

Download data: CEL, XLS

Series

Accession:: GSE8681

ID:: 200008681

Select item 20000867911.

Gene expression in mouse white adipose tissue

(Submitter supplied) Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse white adipose tissue (WAT). The early transcriptome changes in WAT were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Their gene expression responses between 4 to 24 hr after treatment showed a common set of early gene expression changes indicative of an integrated stress response (ISR). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL, XLS

Series

Accession:: GSE8679

ID:: 200008679

Select item 20001740412.

Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes

(Submitter supplied) Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes. Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) reduces triglyceride levels in adipocytes. AMP-activated protein kinase (AMPK) was recently demonstrated to be involved in the emerging pathways regulating this response. This study investigated the role of AMPK and inflammation in lowering triglyceride levels by testing the following hypotheses: 1) A moderate activator of AMPK, such as metformin, and an inflammatory response are sufficient to reduce triglycerides, and 2) Strong activation of AMPK is also sufficient. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
9 Samples

Download data: CEL, TXT

Series

Accession:: GSE17404

ID:: 200017404

Select item 20001488813.

Conjugated linoleic acid activates AMPK and reduces adiposity more effectively when used with metformin

(Submitter supplied) Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) causes dramatic reductions in white adipose tissue in mice but has had limited effectiveness in humans. Determination of the signaling pathways involved may lead to better regulation of adiposity. T10c12 CLA was found to activate AMP-activating protein kinase (AMPK), a central regulator of cell metabolism. Compound C, a potent inhibitor of AMPK, prevents many of the typical responses to treatments with t10c12 CLA including the integrated stress response (ISR), the inflammatory response, the reduction in key lipogenic transcription factors, and delipidation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3808
Platform:: GPL1261
12 Samples

Download data: CEL, TXT

Series

Accession:: GSE14888

ID:: 200014888

Select item 380814.

Trans-10, cis-12 conjugated linoleic acid and metformin effect on 3T3-L1 adipocytes

Analysis of adipocytes treated with trans-10, cis-12 conjugated linoleic acid in conjunction with AMPK activator metformin. The combined treatment results in greater triglyceride (TG) reduction than with the individual chemicals. Results provide insight into molecular basis of the TG reduction.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 4 agent sets

Platform:: GPL1261
Series:: GSE14888
12 Samples

Download data: CEL

DataSet

Accession:: GDS3808

ID:: 3808

Select item 20010023715.

Gene expression profile of peroxisome proliferator-activated receptor delta (Ppard)-overexpressing RAW 264.7 macrophages treated vehicle, GW501516 or interleukin-4 (Il-4)

(Submitter supplied) Investigation of whole genome gene expression level changes in GW501516 (a Ppard ligand) or Il-4 treated Ppard-overexpressing RAW 264.7 macrophages as compared to vehicle. Alternative activation of adipose tissue resident macrophages inhibits obesity-induced metabolic inflammation. In the current study we profile genes regulated by two M2 inducers, Il-4 or Ppard agonists and find that alternative activation promotes the cell survival program, while inhibiting that of inflammation-related cell death.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10192
9 Samples

Download data: PAIR

Series

Accession:: GSE100237

ID:: 200100237

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000213116.

Wild type and Ppara KO, CL time course

(Submitter supplied) Time course og gene expression changes in white fat of wildtype and Ppara KO mice during treatment with the adrb3 agonist CL 316,234. Keywords: time-course

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1226
Platform:: GPL81
8 Samples

Download data

Series

Accession:: GSE2131

ID:: 200002131

Select item 122617.

White adipose tissue remodeling: role of peroxisome proliferator-activated receptor alpha

Temporal analysis of epididymal white adipose tissue during remodeling induced by the β3-adrenergic receptor (Adrb3) agonist CL-316,243 in peroxisome proliferator-activated receptor alpha (Ppara) knockouts. Ppara is upregulated by CL-316,243.