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| Status |
Public on Sep 11, 2014 |
| Title |
AKT pathway genes define 5 prognostic subgroups in glioblastoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Third-party reanalysis
|
| Summary |
GBM samples were clusered using gene expression of AKT pathway genes to reveal at least 5 GBM AKT subtypes, having distinct DNA copy number alterations, enrichment in oncogenes and tumor suppressor genes and patterns of expression for PI3K/AKT/mTOR signaling components.
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| Overall design |
Gene expression was profiled on 39 GBM samples plus 6 normal controls from UCSF, as well as 9 GBM samples plus 8 normal controls from MDA. This data was combined with published GBM gene expression data from MDA [GSE4271] and UCLA [GSE4412] obtained on the same platform to reveal GBM subtypes based on AKT pathway genes.
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| Contributor(s) |
Joy A, Ramesh A, Smirnov I, Reiser M, Misra A, Shapiro WR, Mills GB, Kim S, Feuerstein BG |
| Citation(s) |
24984002 |
| Submission date |
Sep 11, 2014 |
| Last update date |
Sep 11, 2014 |
| Contact name |
Joseph Costello |
| Organization name |
UCSF
|
| Department |
NeuroSurgery
|
| Street address |
1450 3rd St
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL19180 |
[HG-U133B] Affymetrix Human Genome U133B Array [Custom Brainarray v16 ENTREZG CDF] |
| GPL19184 |
[HG-U133A] Affymetrix Human Genome U133A Array [Custom Brainarray v18 ENTREZG CDF] |
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| Samples (124)
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| BioProject |
PRJNA260806 |
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